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Gold has always been used as a form of money since 560 BC. And even today, it is considered by many cultures as a valuable and long term investment as well as a safe haven in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

times of crisis. Gold and other precious metals are assets that are both tangible and liquid and hence considered safer than other investments. Most people believe that if t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e monetary or financial systems collapse, gold would still retain its value. Selling gold accumulated over the years could be the answer out of financial ruin. Thus gold as a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

n investment is a prudent idea. Even central banks across the world are believed to retain large reserves of gold.

Today, gold trades in all the big financial markets around

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

the world. It would not be surprising to note that a current market price for gold is being established in some market at any time of the day or night. Two of the most impor

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

tant world markets are in London and New York.

The London market is one of the oldest in the world as well as the largest for physical gold. The term ‘London gold fix’ which

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

has been used since 1919 is used in contract arrangements across the globe. The New York market is particularly noted for the volume of "paper gold transactions" such as futu

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

res contracts that are traded on the exchange. The other important gold markets are in Zurich, Tokyo, Sydney and Hong Kong.

Today, like all investments, the price of gold is

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

governed by demand and supply as well as hoarding and selling. The latter plays a more important role as far as the affectations in price are concerned because all the gold t

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

hat is mined comes on to the market at the right price. Thus, given the huge quantity of hoarded gold compared to the annual production, the price of gold is affected by chan

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es in sentiment rather than changes in production or demand on gold jewelry.

Why invest in gold?

There are some fundamental reasons why the price of gold

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

will tend to see an incline in the next few years and gold as an investment will be considered a wise move.

Since 2001, Gold is believed to have doubled in value.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n a simultaneous reaction the U.S. Dollar index has fallen by about 23% while the Dow Industrials have only risen by 16%. That is why most analysts believe gold will continue

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

its rise in a bull market and gold as an investment will continue to flourish.

Another important reason for gold prices to increase is the continuous rise in worl

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

oil prices. The factors leading to this phenomenon are the Middle East crisis, OPEC’s commitment to higher oil prices and more importantly the potential decrease in oil supp

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lies with a growing demand of oil from developing nations. Subsequently, as oil prices rise, so do the gold prices as it spurs inflation in the economy.

Last but n

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t the least it is the $63 million fiscal gap that is contributing to the rise in gold prices. The fiscal gap is a measure of the difference between projected future governmen

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t expenditure and tax receipts. This means that, with a $63 million fiscal gap, the government is in debt or technically bankrupt. To manage this debt, it can print money whi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

h will only lead to inflation; thus precious metals such as gold will remain one of the few safe investments that not only protect us against inflation but also unrestrained

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

government expenditure.

Thus, buying gold as an investment at today’s prices would offer considerable gains and protection from financial problems in the future

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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