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After a strong performance in 2003, 2004 and 2005, the Japanese stock market was essentially

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

flat during 2006 until a strong December rally brought the most widely traded Japan ETF (EW

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

) up just over 5% for the year.

What lies ahead for Japan as the world’s second largest eco

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

omy and stock market? Will the Japanese yen finally begin to appreciate and benefit foreig

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

investors? Is Japan still an excellent play on the overall Asian growth story? When will t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e Japanese consumer begin spending again? Why is Japan one of the few countries in the world

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to have a trade surplus with China and why is Japan able to hold on to its industrial base s

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

o much better than America? Are Japanese large multinationals the place to invest or should

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nvestors target the smaller and more innovative companies?

In 2006, small and mid cap ETFs

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ed the way in Japan and these ETFs could also do well in 2007. The best performing ETFs trac

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ing Japanese markets were WisdomTree’s Japan Small Cap ETF (DFJ) and its Japan High-Yielding

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Equity ETF (DNL). Both ETFs were introduced on June 16th. Other key questions for long-term

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ETF investors are how will the Japanese - America alliance evolve and could Japan be moving

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

owards excessive nationalism? What is likely to be the impact of Japan’s demographics on inv

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

estment opportunities and returns?

These are all important questions. Why don’t you get to

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

he bottom of these questions yourself by joining me in May 2007 as I lead a ten day investme

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t tour of Japan http://japaninvestortour.wordpress.com/about/

This will be a trip of a life

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ime and will be a fascinating immersion into Japan’s stock market, economics, politics, cult

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

re and history as well as provide you with the opportunity to learn more about specific Japa

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ese companies. Join me to find out what place Japan should have in your global ETF portfolio

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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