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"Laughter is the shortest distance between two people." ~ Victor Borge

"Good humor is one of the preservatives of our peace and

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

tranquility" ~ Thomas Jefferson

"If I can get you to laugh with me, you like me better, which makes you more open to my ideas."

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

John Cleese

Have you noticed that couples who laugh together remain together and seem incredibly happy? How can we better disso

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

lve an argument or a marital storm but with a joke and some hearty laughter?

It is really sad when you tell a joke or make a wit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y comment and the other person doesn’t laugh. I know some people who lack this ability to laugh on demand. My friend’s wife is on

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of them. His theory is that she cannot appreciate humor because she is too dumb; she lacks the ability to comprehend the subtlet

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ies of language and situations. I think I agree with his opinion and will go forward by making a generalization, adding that thos

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

without a sense of humor are also a bore.

Laugh is always the best medicine. It has been said over and over again that laughter

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

is healing. Laughter improves blood circulation and digestion, decreases stress, increases self-confidence and, by strengthening

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

the immune system is indeed very healing. Not bad for such a simple activity. According to popular belief, we use 43 muscles to f

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

own and opposed to 17 to smile. Unless you want to exercise your facial muscles, a smile saves physical energy while providing us

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

with abundant cosmic ones. Your level of serotonin, the happy hormone, also soars.

If you need a crash course in the use of your

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

laughter glands, the best triggers are comedies. There are some great movies, books, plays, etc. that will put you right in the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ood. Try them out.

I particularly recommend silly but creative and intelligent comedies, such as the theatrical musicals "The Pr

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ducers." I swear, I have seen nothing funnier, or "Crazy for You;" the movies and everything else made by Mel Brooks; the operas

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

"The Marriage of Figaro" and the "sequel" "The Barber of Seville," the plays by Oscar Wilde, all books by Bill Bryson, all of Dav

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Barry’s writings, "I Love Lucy" reruns, etc. There are simply hundreds of things that will help you lighten up.

One little hicc

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

p: don’t go on watching TV!

A Word of Advice Ladies and Gents: Find a way to laugh everyday. Also, in the morning, look at each

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

other and smile for one minute. This will be a great way to start your day. Also, exchange funny clean jokes with your email con

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

acts. It is imperative to find time for one hearty laughter a day, at least. If you can laugh with each other, so much the better

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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