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    When there is something wrong, we need to fix it.
    Then, if our business is low in profit, we fix it.
    If our leg is broken, or our bowel is blocked, we fix it.
    If our car gets stolen, we fix that, we ring the police and insurance
    Right?
    If we have a back pain, we fix that too, we go to a back doctor.
    OR even if our memory is lost, we go to a hea
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    d doctor.
    But sometimes we go to the doctor when there is no problem
    Just not happy. And we call this, self help.

    Now there are many definitions of “just not happy”. If you go to a person who specializes in ADD, you will have ADD. And if you are not happy, and go to a person who specializes in Depression, no doubt you have depression. And if you go to a seminar th
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    at teaches about consciousness, then your unhappiness is caused by unconsciousness. Or if you are unhappy, and go to a seminar on relationships, it’s your relationship that is to blame. And this is why, self help guru’s drive fancy cars. Bu the problem is not caused just by the guru doing “in my theme” diagnosis. You chose the seminar, or the book. Self help, does not necess
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    arily mean self diagnosis.

    Beware of any diagnosis. There are millions of experts in “psychology of happiness” who read one Deepak Chopra book, or two, and who will give you advice. Free. Which is what it is usually worth. Maybe you are normal. And the diagnosis just feeds your desire to “brand the problem”. Because usually with a diagnosis comes a solution. At a price. The
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    price is not dollars. The price is time.

    To brand a steer at a rodeo, the cowboy, or cowgirl lassoes the steer. Because the steer runs everywhere. It knows it’s going to be captured, and the brand is going to hurt So, it runs. Where does it run? It doesn’t care where it runs. It runs. It runs everywhere where the cowboy or cowgirl is not. The winner of the competition is t
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    he cowboy or cowgirl who brands the steer fastest. Because why waste time. Lets get it over with.

    Now the steer thinks something is wrong with it. Right? It thinks “oh Shit” I must have food allergy, or hypertension, or mad cow or something, so it goes running around trying to find a solution. But really, there is nothing wrong. In fact if there was something wrong, the ste
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    er would be killed and eaten.

    So this is the same when I work with people. They are sometimes unhappy. So they read self help books, and go to seminars and get some ideas that something is wrong with them. They learn to walk on hot coals, or break an arrow, or dance to drums. Like the steer, anything is better than the lasso. And even if they read a book they only say that
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    the book was good, if it confirms what they think. So, self diagnosis, and self help is an oxymoron. Just look in a health food shop, many of the people are sick and stay that way because of only one thing, because they think they are sick. They often treat themselves for illness, and therefore never get a chance to be well.

    Another way to avoid the lasso, is to become spir
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    tual. That means, for most unhappy people that they can now condemn the cowboy or cowgirl, and not run away. There should be peace and happiness in the world. So instead of really becoming happy, they try to coat the world in a layer of leather, instead of wearing sandals.

    What are the parallels between what I do, and the lasso? Maybe the dentist is the better metaphor. You
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    really never ever want to go to the dentist. Although I did meet one lady who had orgasms in the dentist chair. Most of us, go to the dentist, because we have an ache or need a check up. We tried brushing and using fluoride in the water, and cloves, and so many different pain killers, but in the end, really it’s simple. Go to the dentist.

    But in the self help industry, wel
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    l, is there ever a goodbye? If I think I have a problem (AKA the self help guru) then, I always have that need to fix it. And like the steer I will run around and around, reading books, and listening to people who are not happy, in order to get happy. I might even move to a far off country, run away from the challenges, find a new lover, do anything really. But the last thin
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    g we want to change, like the last resort of going to the dentist, is our problem.

    Here are a few laws, a few simple laws. If you apply these laws, you might change the cause of your own, and others unhappiness. I hope they are of interest to you. Then, instead of trying to fix and make yourself better (which you can’t) you might start to smile and celebrate the beauty of l
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    fe, by trekking up to the summit of a hill in Nepal, or kiss a baby instead of trying to fix what isn’t broken.

    • Everybody spends 50% of their life energy, unhappy.
    • All depression is caused by the addiction to happiness
    • Blaming yourself or someone else for unhappiness perpetuates it.
    • Being right, causes pain.
    • For everything you fix, another thin
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    g to fix is born
    • There is a beauty in challenge, as long as you see it so.
    • No pleasure on earth will make you happy for long.
    • The purpose of relationship is not happiness
    • Everybody is a mirror of you. Like them or not.
    • To be loved is to be supported and challenged
    • To find happiness through challenge is creativity
    • Creativity is
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    beauty, growth and happiness.
    • To fix a challenge is to birth sadness.
    • Love and stress cannot coexist
    • Stillness is love.
    • Stillness is not static. It is loving kindness in action
    • Humility and immunity are one in the same topic
    • Looking for solutions, causes the problems.
    • If your partner doesn’t challenge you, life will.
    • D
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    eath is the symptom of lack of challenge.
    • Peace is another word for dead.

    To write this material is a non commercial exercise. Because two things drive the steer around the corral. Hope (for an escape) and fear (of the future). That is the basis of the self help industry. Create hope, eliminate fear. But these laws of nature say, “there will always be support and cha
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    lenge so don’t hope for a life without some unhappiness, and there will always be another discomfort in the future.

    But if we spend our life, with false expectation. Based on some movie, like “What the bleep” or we are running toward some mirage of self peace and spirituality which makes our love conditional on getting supported, then we will end up in a box, surrounded by
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    toys, and people who agree with us, and unhappy. Why not have realistic expectations. The cowboy or cowgirl is going to lasso you eventually. They are mother nature. You can’t run from it. If I were that steer. I wouldn’t run. I’d stop, get branded, share the prize money and go back to the coral where the cows are. Realistic expectations, understanding human nature, frees yo
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    u to love, instead of running around trying to follow some ideal that the author never lived.

    Today, learn to laugh at the difficulties, smile at the challenge. Stay silent instead of talk. Listen instead of action. Look for support and challenge in every circumstance and welcome both equally. Learn to love life by having an honest appreciation of the laws that make it so.
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    See where people have filled their head with ideas, which is their right, and will spend the rest of their living days, searching for fantasies. Religious fantasies, relationship fantasies. Blaming the world. See them, as a part of you, and smile. We can’t change the fact that our ego gets off on fantasy, just smile and recognize yourself and instead of reacting, embrace it


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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