Tags |
|
|
Links |
|
|
E-Articles - From Breakup To Bliss - The Prevalence of Ambivalence
I feel moved to write this article because of a dating situation that occurs very frequently but isn’t explained by the simple rules of dating found in most books. I will use a case example as an illustration.
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
Henry and Yvonne (not their real names) met online. After a few email conversations they got together for coffee. They hit it off and were soon dating. According to Henry, they were head-over-heels in love
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
and after six months they got engaged. Then things started to unravel, and Yvonne seemed to grow more distant. Henry wanted to make things better, Yvonne wasn’t sure. However, the thought of breaking up wit
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
Henry filled her with dread. Henry had always treated her well, though sometimes it seemed like he wanted more than she could give.
After a year they broke up, but in a month they were talking again. He wan
After a year they broke up, but in a month they were talking again. He wan
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ed to feel love like it had been before, and she didn’t want to lose the best thing she’d ever had. But still she wasn’t sure.
One could say that this problem was due to infatuation wearing off, denial and gu
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
lt pushing her into accepting the engagement, and then loneliness bringing them back together after the breakup.
However, this assessment is based on one significant false premise. It assumes that “in-love”
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
nd “not-in-love” are black and white concepts, and it assumes that infatuation, if it fades, becomes ”not-in-love.”
The truth, unfortunately, lies somewhere in between, and it is necessary to deal with this “s
The truth, unfortunately, lies somewhere in between, and it is necessary to deal with this “s
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ades-of-gray” complexity if one is to be successful in life and love.
Henry and Yvonne both felt very high romantic chemistry at the start, but once infatuation wore off her true level fell to “high,” while hi
Henry and Yvonne both felt very high romantic chemistry at the start, but once infatuation wore off her true level fell to “high,” while hi
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
remained “very high.” If her feelings of romantic chemistry had fallen to “medium” or less, then one could say that she had fallen out of love. But in fact her chemistry remains “high” (though not as high as
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
Henry’s). This causes her to feel ambivalent. Maybe she can find someone where the chemistry is stronger, but maybe she can’t, at least not in someone who treats her as well as Henry does. So she is stuck.
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
he doesn’t know whether to proceed with him or not. She doesn’t want to give him false hope, but she doesn’t want to lose him either. She doesn’t know what to do. This drives him crazy, and he also doesn’t k
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ow what to do. Her ambivalence fuels his insecurity which in turn causes him to work harder at the relationship which in turn causes her to feel more confined and more like leaving. It is a vicious circle.
T
T
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
is, or a variation of it, seems to occur all the time, hence the title of this article “The Prevalence of Ambivalence.”
So what’s the solution? First there must be enough emotional maturity to be able to reco
So what’s the solution? First there must be enough emotional maturity to be able to reco
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
nize the problem and constructively work on it. In this example Henry’s emotional maturity was a little higher than Yvonne’s, and enough to try to get a grip on the situation.
The partner who feels higher che
The partner who feels higher che
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
istry (Henry) must patiently allow time for the ambivalent partner (Yvonne) to sort out her life goals and decide how (or if) this relationship fits into them. This can be very hard to do. Henry needs to work
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
on his own personal growth to be able to handle it. Yvonne will probably need to date other people as a part of her decision process. Therefore Henry will also need to date other people, but for different rea
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
ons (his emotional health and self-protection). (No one should date others out of spite or revenge or an effort to make the other person jealous.)
An important part of the solution is to seek advice and supp
An important part of the solution is to seek advice and supp
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
rt from someone who understands this sort of situation. Friends will often give simplistic views (“forget her’” or “move on”). This is an ideal opportunity for Henry and Yvonne to get assistance to help them
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ocus on personal growth, which usually means gaining new knowledge about how relationships work. It is also important to gain the ability to apply this new knowledge! My book "Love Is Not A Game (But You Shou
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
d Know the Odds)" is an excellent source of information about how to measure chemistry and maturity, and how to deal with the issues that arise from an imbalance of these factors.
Copyright 2006, Randy Hurlbur
Copyright 2006, Randy Hurlbur
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.e-article.org.ua/article/200303/e-article-From-Breakup-To-Bliss--The-Prevalence-of-Ambivalence.html">From Breakup To Bliss - The Prevalence of Ambivalence</a>
BB link (for phorums):
[url=http://www.e-article.org.ua/article/200303/e-article-From-Breakup-To-Bliss--The-Prevalence-of-Ambivalence.html]From Breakup To Bliss - The Prevalence of Ambivalence[/url]
Related Articles:
An Introduction To Mortgage Refinancing
Bookmark it:
|