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Initially in astronomy, there is not a huge financial investment. Just go outside and look up. Instant success. You see stars.

But then, there comes a thirst for more. What are the stars made of? Why do

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

they move in the sky? And what’s all this winking and twinkling about? Questions you haven’t thought of since you wore Superman underwear. These worthy inquiries are easily answered in a trip to your loca

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

library.

Then it really happens. You find out your very own town has an astronomy club. "Come see the stars!", they entice you! "Free Star Party this Saturday!" Armed with a thermos of hot cocoa and coo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ies your wife made, you tramp up Star Party hill. And you see it all - not just the stars and galactic nuclei, but all those TELESCOPES.

WOW.

Your wife is not happy about trading the car for a telescope

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

. Call her crazy, but a telescope doesn't pick up the groceries or take kids to ballet. In fact, it's a gadget to look at things that have been around since before either of you were around. You’re just a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

l-fired up on doing it now. And yes, most of those sparkly things up there will be up there when you retire, so why not just wait until then?

"Because the purpose of life to experience happiness, which c

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n only be experienced in the present moment," explains the Dalai Lama, quite patiently.

"But the Dalai Lama does not have four children and two mortgages," your wife counters. So what are you to do?

Ast

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ronomy club telescopes are available for members, but what if you want something of your very own right now? (We are, after all, Americans.) And you want to share astronomy with your kids, and you're not

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ikely to share an expensive telescope with those grubby hands. There must be a happy alternative. But what?

Go get a raft. The inflatable kind you have lurking somewhere in your garage already. Set it up

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

on the grass, and pull out a pair of binoculars. A good pair. Add cocoa and cookies, and you have an instant star party worthy of any amateur astronomer.

How to pick a good pair of binoculars? Here are s

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

me ideas that may work for you (excerpted from Backyard Astronomer’s Guide by Dyer and Dickinson):

Larger main lenses mean brighter images, but for most people, a 50mm lens is a practical handheld limit.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Binoculars with a 7mm exit pupil are easier to bring to correct position in front of the eye, an advantage for young people and beginners of any age.

Higher magnification means better resolution, but it

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

also means more stringent optical-quality standards to produce good images. It also results in amplified jiggling during handheld operation. This factor alone limits binocular magnification for handheld a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tronomical viewing to 10x.

Put it all together, the most popular sizes are 7x50 and 10x50. If you prefer smaller and lighter, go for the 7x42 or 8x42. Why not just go for the 10x50s, since biggest means

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

best? Well, because aiming and observing through binoculars at night is much easier for some than others. In our experience, 7x50s are much easier to use. On the other hand, 10x50s yield fainter stars and

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

more Moon and celestial object detail. More detail makes sense, but why are dimmer stars more apparent? Part of the reason is that the smaller exit pupil helps avoid the edge-of-eye aberrations (producing

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

sharper stars), but mainly, it is that the higher magnification in effect spreads out the sky background, darkening it in the process.

Roof prism binoculars are more compact than porro prism in sizes und

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

er 42, and are generally more costly. For general astronomy binoculars at a reasonable price, we recommend porro prism models in 7x50 and 10x50.

RECOMMENDATIONS for general astronomy glasses:
These

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

wo stand out, both in the $200 range: Vista 10x50 by Orion and Ultima 10x50 by Celestron. Both are 27 ounces (exceptionally lightweight for 50mm binoculars) and very sharp 5.3-degree fields and good eye r

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lief. In the $100 range, the Bausch & Lomb 10x50 and 7x50 Legacy are ideal beginner binoculars for astronomy. A lightweight tripod and L-adapter are great additions for an upgrade. Go enjoy your night sky

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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When marketing to the New Middle Aged group, those who are fifty and sixty plus, be sure and use your instincts and emotions, they do.

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