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Across the nation and around the world you will find hospitals that have oncology or cancer programs

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

geared towards childhood cancer. Through research and trials, it is evident that the diagnosis and

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

treatment of childhood cancer is different than treating the disease in adults. For this reason, i

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

is imperative when seeking cancer care for your child that you do research and make sure that you a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

re going to the hospital that is right for your child.

Some pediatric cancer programs might concent

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ate on one or two types of cancers and treatments whereas others, such as St. Jude Children’s Resear

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ch Hospital, treat all types of childhood cancers as well as doing research and clinical trials. Be

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

fore you choose a hospital to treat your child’s disease, you need to make sure that you are going t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

a hospital that will give your child the best chance in the fight against cancer.

When researching

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

children’s hospitals and oncology programs or cancer care, you should have a list of questions that

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

are relevant to his/her cancer and ask each hospital the same questions for comparisons sake. Quest

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ions to include in your research are to ask about research, clinical trials, success rates, number o

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

f cancer patients they see each year, whether they have ever treated a child with your child’s type

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

f cancer, which cancers they specialize in, if they offer support groups and do they offer family-ce

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ntered care which allows families to be a part of the treatment plan.

Since pediatric cancer care i

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

different than cancer treatments for adults, many families opt to go to a children’s hospital for c

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

are. However, this is a very personal choice. Whether you choose cancer care at your hometown hosp

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ital or choose to travel and stay at a larger hospital, make sure that you are getting the best poss

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ble care for them that you can. Since you are their voice and their advocate, you have to do what y

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ou can to make sure that you are giving them the best opportunity to fight and beat childhood cancer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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