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E-Articles - The Pain Scale - Before and After Science
Which hurts more: a Ford F-350 loaded with manure running over your foot or taking a muffin tin out of the oven barehanded? Which hurts more, being hit on the head with a claw hammer, or bashing
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
your thumb, splitting the its nail to the cuticle with a claw hammer? A migraine everyday for the rest of your life, or a root canal without Novocaine?
Doesn't the body run to the rescue in momen
Doesn't the body run to the rescue in momen
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ts of intense pain by shutting down, so that you go into shock? I can't even remember the most intense pain I've ever felt, but I do remember, vividly, the spinal headache I suffered for 4 days un
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
il I got a blood patch. Of course the cause of that headache, a myelogram, took place on a holiday weekend.
Here's my new pain scale, for the less evolved members of our species. I think it's mu
Here's my new pain scale, for the less evolved members of our species. I think it's mu
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ch more accurate, although less scientific than the current version which assigns a value of "10" to the "worst pain you've ever felt." This method assumes that one was conscious while that pain o
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ccurred and doesn't assign bonus points for duration of pain.
10. Post surgical stab wounds and pain from surgical paws pushing organs and stuff around in your body. 7 core pain points, 4 durati
10. Post surgical stab wounds and pain from surgical paws pushing organs and stuff around in your body. 7 core pain points, 4 durati
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
n points, and a possible 1 indignity point=10-11.
9. A sunburned walk across a hot parking lot covered with granite chips at the beach, while carrying beach chairs and an umbrella . 6 core pain po
9. A sunburned walk across a hot parking lot covered with granite chips at the beach, while carrying beach chairs and an umbrella . 6 core pain po
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
ints, 2 duration points. If the heat from the asphalt causes those wavy heat lines, add a point. If you drop the stuff you're carrying, subtract one duration point, add one indignity point.
8. De
8. De
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ntal work without Novocaine. 6 core pain points, 2 duration points.
7. Poison Ivy. 3-5 core pain points depending upon where you scratched and spread the infestation, 3 solid duration points. I
7. Poison Ivy. 3-5 core pain points depending upon where you scratched and spread the infestation, 3 solid duration points. I
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
now this is a high rating for poison ivy, but think about it; that's why the faux-objective scales don't work.
6. Broken bones. 5 core pain points, one "itch" point. Subtract one point if you rem
6. Broken bones. 5 core pain points, one "itch" point. Subtract one point if you rem
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
ove the cast one week before it's due to come off.
5. Home dentistry, bone setting, or stitches. In my experience, I've done okay with bones, but they've healed crookedly. All 3 ill-advised pra
5. Home dentistry, bone setting, or stitches. In my experience, I've done okay with bones, but they've healed crookedly. All 3 ill-advised pra
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
ctices begin with 5 core pain points, and under no circumstances, except dangerous dosages of Advil, can this number be lowered. Home stitches are almost always higher. Home dentistry is messy an
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
in all cases I've experienced, rapidly approach 10. On that subject, trying to pull my own tooth with a Leatherman in the men's room at work. went straight to a ten when the torque from the devic
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
e shattered the tooth. Collateral pain damage rippled through the office, and while it can't be quantified, can also not be ignored.
4. More than 15 stitches. 3-4 core pain points, 2 solid durat
4. More than 15 stitches. 3-4 core pain points, 2 solid durat
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
ion "itch" points.
3. Any procedure performed by a physician preceded by the phrase, "This may hurt", is an automatic 3 core pain points.
2. Burns, metal filing splinters. 1-2 core pain points,
3. Any procedure performed by a physician preceded by the phrase, "This may hurt", is an automatic 3 core pain points.
2. Burns, metal filing splinters. 1-2 core pain points,
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
1-2 duration points.
1. The question, "feeling any better today?" when asked by the same person who asked yesterday. 1 core pain point, 1 duration point, but subtract a point because the person re
1. The question, "feeling any better today?" when asked by the same person who asked yesterday. 1 core pain point, 1 duration point, but subtract a point because the person re
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
ally does mean well.
This is a rough draft in the sense that I've made no effort to make this a universal list. It's personal. The point I wish to make is the variety of flavors pain comes in, an
This is a rough draft in the sense that I've made no effort to make this a universal list. It's personal. The point I wish to make is the variety of flavors pain comes in, an
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
d the idiocy of asking a patient to use as a reference the "worst pain they've ever felt". For me, that "worst pain" is a discography, a truly medieval test. It's the one when the anesthesiologis
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
says, "You're not going to like me after this procedure." And why would that be? "Because it's my job to keep you awake, out of shock, for the next two hours."
When you hear that, it's going to
When you hear that, it's going to
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
be 2 hours of bad road. God, in his mercy, has blanked from my mind what that discography felt like. All I remember is that I was awake, it was 2 hours, and may approximate hell. God Bless, Coli
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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