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High living has always been associated with the use of perfumes. In the old days with royalty people espousing the need for fragrances, the bourgeois society soon follo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

wed.

Perfumes from natural odorants like sandalwood or musk were preferred. In today`s world due to illegal trafficking and species endangerment, natural odorants are

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

replaced by synthetic aromatics. Both have their advantages and disadvantages. Aromas like musk from natural ingredients are extremely complex and have been impossible

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

to imitate through synthetic aromatics like nitro-musks or macrocyclic musks. On the other hand, synthetic aromas like ozone, marine, metallic, etc., have no parallel o

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lfactory relationship in the natural odorants.

So nowadays with modern technology of perfume manufacturing and synthetic aromas, new categories have been created. Cate

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

gories that can be best described as: 1 - Bright Floral - very popular and meant for almost everyone and all occasions; 2 - Woody - it evokes the forest refreshing smel

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

l; 3 - Green - it has a lighter fragrance and is meant for casual wear; 4 - Oceanic - it is very popular among the younger generation; 5 - Spicy Fruit - a good choice f

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

or tropical weather or during summer; 6 - Oriental - it is meant for special occasions. Spicy scents.

It is very important the composition of perfumes, because the rig

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ht combination of scents (as rose, jasmine, cola), modifiers (esters), blenders (linalool, hydroxycitronellol) and fixatives(like resins, wood scents and amber), can pr

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ovide the unique smell by which brand name perfumes are so famous and desired for. Some famous brand name perfumes are:

1 - Eau de Cologne (1709)
2 - Chanel No. 5

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

(1921)
3 - Opium YSL (1977)
4 - Azzaro Pour Homme (1978)
5 - Anais Anais (1979)
6 - Poison Christian Dior (1985)
7 - Eternity Calvin Klein (19

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

88)
8 - Envy Gucci (1997)
9 - Nu YSL (2001)
10 - Rose 31 (2006)

Also, preservation of perfumes is of vital significance as it degrades if kept carelessl

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

y. Previously all perfumes used to come in open bottles with caps. These bottles kept the fragrance intact for about a year. As it was used, the level of the perfume we

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nt down, and it was exposed to oxygen contained in the empty space of the bottle. This eventually changed the perfume`s fragrance. Heat, light, oxygen, and extraneous o

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rganic materials, further distorted the fragrance. Thus glass bottles, though extremely decorative, allowed light, and contributed to the degradation of the scent.

It

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

is now a well known fact that light-tight aluminum bottles are best for the preservation of perfumes, especially when they are refrigerated at low temperatures from 3 t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

o 7 degree Celsius. The oxygen contained inside the bottle cannot be removed completely but it can be minimized by the use of rollers instead of open bottles. Further m

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

inimization of oxygen exposure can be attained by the use of sprays.

Thus almost all modern day perfume come in spray bottles, which isolate the perfume from mixing wi

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

th outside oxygen, skin, detritus, and dust, thereby promoting the longevity of the olfactory quality of the perfume.

This article is under GNU FDL license and can be

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

distributed without any previous authorization from the author. However the author?s name and all the URL?s (links) mentioned in the article and biography must be kept.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Selling is largely the most difficult part of the overall investment/trading equation.

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