E-Articles - Health and Fitness

When it comes to dental whitening techniques and bleaching methods, there are several options to consider. From toothpaste with whitening ingredients to bleaching chewing gum, the di

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

versity of products available may overwhelm some people's ability to carefully decide on the best option and thus lead to improper use of some products. What is worse, it may lead to

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

use of bleaching products whose formula isn't effective, or that are dangerous for a normal dental health. I will try to highlight some dos and don'ts of tooth whitening, in order t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

help anyone considering tooth whitening to achieve optimal whitening results without compromising their dental health.

The first bit of advice is rather obvious: no matter what mir

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

aculous product you have seen on TV, you must consult a dental care professional before you start using any products. Your dentist will be able to guide you through the sometimes dif

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ficult process of choosing the tooth bleaching method that best suits your needs based on your mouth's health, how much whitening you need and how quickly you want results. Then, he

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ill recommend what tooth whitening tray you should use, and also tell you what product is best for you. A dental health expert will design a customized dental tray that fits your own

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

mouth and tooth size.

A professional will also be able to suggest what to do with any artificial dental work you may have (bonding, caps, fillings, bridges, etc.), as bleaching wil

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

l whiten natural dental pieces only. If necessary, he will be able to replace any non-natural piece with a whiter one, just to ensure all your teeth will be the same color once the w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

itening treatment has succeeded.

Stay away from generic trays. These non-customized whitening trays will not fit your mouth perfectly, and may have several undesirable complications

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

. For example, a tray that does not fit your teeth may allow the bleaching gel to be swallowed, and they also may cause injuries to your mouth's soft tissues. Besides, these trays of

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ten come with bleaching products that are ineffective, acidic or even toxic.

Once you have your own customized tooth whitening tray and bleaching product, you must take a little tim

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

to prepare your teeth for the whitening treatment.

Always brush and floss your teeth prior to applying the whitening tray. There is a good reason for this: the bleaching gel works

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

better and faster on clean teeth. So, you will end up using less gel.

Try to use your tooth whitening tray while sleeping. This way the whitening product will remain in contact with

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

your teeth's surface long enough to reach maximum bleaching effectiveness. Besides, if you don't have to use it through the day you will experience less trouble on your normal dayti

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e activities, mainly because it may be difficult to speak while having a tray inside your mouth, even when they are pretty thin.

Visit your dentist on a regular basis to allow him t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

o closely follow the evolution of the whitening treatment, and also to let him fix any problems that may appear. Remember, your teeth will resist treatment, but your gums may not. Le

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t your dentist assess any possible damage to the soft tissue and give you instructions on how to avoid it. Also, keep in mind that tooth whitening is basically a chemical treatment,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

o avoid any kind of accidental swallowing of the bleaching product. More important yet, do not whiten your teeth if you are a pregnant or lactating woman, or if you are under 13 year

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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