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This Article details seven great ways to improve your smile. I have been a practicing cosmetic dentist in N.Y.C. for over 20 years and these are my favorite recommendations!

The number one way is to bleach your teeth! This can easily be done with Crest white stri

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ps, tray bleaching or chairside bleaching with your dentist. Tray bleaching is my preferred method since it can easily be touched up periodically and very affordably in a night or two. Chairside bleaching is ok, but it can require multiple costly treatments and touchups are can be expe

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nsive if not included in the initial fee. White Strips have the same cost each time they are used and many of my patients have found them yucky!

The number two way is bonding. If you have misshapen or rotated tooth or if the shape of your teeth create a smile you don’t like

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

then a trained dentist can change your smile painlessly by adding a bonded composite material. Teeth that have been minimally bonded can look great and tend to look more natural than a fully veneered smile. When people see your new smile, they usually notice your own, natural teeth

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

, not the small altered portion. Bonding, combined with a prior bleaching treatment, is one of your best options for teeth that look wonderful for years Although bonded teeth can look great for years, they do sometimes pick up stain and the texture bonded surfaces can change over time

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

The number three way is Crowns or implants. Use these options to fix any individual unsightly or missing tooth. All Porcelain (metal free) Crowns cover a tooth and tend to strengthen it, while remaining extremely aesthetic. They do require considerable reduction of tooth.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Although crowns often improve a tooth’s ability to withstand the vertical forces involved with chewing, they sometimes weaken its ability to withstand horizontal forces (dentists don’t like to make crowns for prize fighters!). If you need a single tooth replacement, an implant is often

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

a terrific way to replace it assuming you have enough bone remaining in the space to hold an implant. To have an implant tooth, first your dentist inserts an implant in the bone where you lost a tooth. The implant almost looks like a titanium version of the plastic inserts people place

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

into plaster walls to hold screws. After the implant has been in your mouth from 4-6 months it’s ready for your dentist to screw in a post and fabricate a crown. Implant crowns also can be all porcelain (metal free). Sometimes implant sites need to be grafted with bone prior to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

mplant placement to improve cosmetics and the function of the final implant crown.

The number four way is to keep teeth clean. Use an electric toothbrush; my favorite is a ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

c8000/"> Braun Oral-B rechargeable electric tooth brush (any Braun Oral-B rechargeable model is good) Then start flossing! Healthy gums are definitely part of a beautiful smile. No matter how nice your teeth look, if your gums are red and not healthy-looking your smile

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

is unappealing. If you take care of your teeth at home by brushing and flossing and be sure to have regular cleanings at the dentist (every 3-6 months)

The number five way is braces for your teeth. Both conventional orthodontics and dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n.com/generalapp/us/en/index.jsp">Invisalign clear braces(invisible trays) are great options. These days conventional braces move your teeth using wires and brackets on teeth (to hold the wire). The wire exerts tension on different teeth to move them into more des

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

irable positions. Invisalign is relatively new and uses a series of clear invisible plastic trays to gradually move the teeth into a better position. While undergoing treatment patients are encouraged to wear the trays up to 23 hours a day and only remove them while eating and brushing

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

your teeth. Sometimes straightening just the front and side teeth will dramatically improves your smile. With the Invisalign technique, straightening can be accomplished in as few as 18 weeks.

The number six way is to have porcelain laminates placed on your teeth. This i

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s truly one-stop shopping; Teeth are whitened, straightened and made to look younger in about a week or two This treatment option works by resurfacing your front teeth with a thin veneer of bonded porcelain. Porcelain laminates are best for improving smiles in which teeth are worn

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

poorly positioned or discolored. If done well they often last for 10 years or more and porcelain doesn’t show wear as much as bonded teeth do, so that they keep their glossy surface indefinitely.

Also a major advantage porcelain laminates vs. bonding is that laminates are create

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

d away from the mouth. Following instructions of your dentist, their look is created by a highly artistic lab technician who often specializes solely in crafting beautiful porcelain laminates. Your dentist is not necessarily required to be the artist and create the exact changes n

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eded on the spot, the way he would with bonding. However, porcelain laminates do require an exacting bonding technique (bonding as in gluing) and can, over time, pick up stains at the seam where the laminate meet the tooth.

And finally the number seven way is be happy! Think hap

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

py thoughts when you’re smiling! Good looking smiles can’t be fake or forced. If it is true that we smile when we are happy and that we are happy when we smile, then maybe, just maybe, fixing your smile will make you happier. I hope so and I hope this article has been informative

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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