E-Articles - Health and Fitness

Clinical depression is known to impact the lives of one out of every six people in their lifetime. But the sad reality is that the medical community still does not entirely

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

understand exactly what causes depression to occur in one person and not in another.

Yes, we do know that depression is hereditary.

Depression can often be found to run t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hroughout the generations of the same family invading the DNA molecules which make up a particular family’s genes. This causes the family members to be more susceptible to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

depression.

However, there is another school of thought that says perhaps the real reason we see depression run in families is that it is also environmental in that it all

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

depends on how the children are raised. If they see the affects of depression encroaching on the lives of their family and they see the results then they will learn to deal

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

with life the very same way.

Even though we are quite clear that depression runs in families, depression is also seen in those without any family history. Stress resultin

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

g from a variety of issues, trauma, or even prescription medications or illegal drugs have all been known to cause depression.

Riding the ups and downs of depression can le

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ave you even more exhausted that the last wave of depression you faced. Depression is known to run in cycles. You may feel completely fine one day and the next day you may

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

be completely and utterly unable to get yourself out of the bed and out of your night clothes. The dramatic ranges of emotions are well documented in cases of depression.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Many healthcare providers and scientist alike believe that many suffering with depression manifest a chemical imbalance of Norepinephrine and Serotonin which are the feel g

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ood neurotransmitters found in the central nervous system and in the brain.

These neurotransmitters work to help control feelings of happiness and well being. The neurotr

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ansmitter Norepinephrine is thought to be a stress hormone; while Serotonin is thought to control hunger, overall moods, sleep and sexual feelings. When these chemicals g

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

et out of whack they are thought to cause depression.

So if you think about it, when these neurotransmitters are out of balance it only makes sense that the roller coaster

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ride of depression would result. As these levels of these chemical rises and falls thereto go the emotions and feelings associated with them.

The real question is why do s

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ome people experience peaks and valleys with their chemical make up while others seem to be more stable. Again, it begs the question is it really the environment in which y

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ou were raised or is it truly the ebb and flow of the neurotransmitters that alter feelings causing the dramatic impact of depression.

Do you mirror your family because tha

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t is all you know how to do, it is the only way you know to respond or is it that you are genetically and chemically bound to your family and because of that simply have no

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

choice of being impacted by depression.

We need more research and time to study this issue before there is a definitive answer. What we do know is that regardless of the r

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

eason why, we do know that depression tends to run in families and if you have a family member that has dealt with the issue then you should be aware of the possibility that

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

you too could be fighting the same battle one day.

Be aware, seek help early and learn what you can do in order to prevent depression before it takes control of your life.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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