E-Articles - Health and Fitness

Depression is a disease that plays no favorites and can affect anyone of any age at any time. Some of history's most famous and notable peopl

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e were known to suffer from depression. Abraham Lincoln, a man who was considered one of this country's greatest leaders, had an ongoing bat

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tle with depression and suicidal thoughts. At one point in his life, he remained under close watch by his friends because of his mental state

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

. This just goes to show you that anyone can be affected by depression. But how do you get depression? What exactly is the cause?

There is n

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

o known cause for depression. Scientists feel that depression may be a result of several different factors. It could be a combination of envi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ronmental factors, combined with a chemical imbalance in the brain. The causes of depression are going to be different for different people.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

But whatever the cause, treatment is vitally important.

Women are twice as likely to develop depression than men. Hormones may play a big ro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

le in the development of depression in women. During a woman's lifetime, her hormone levels will go up and down like one big roller coaster r

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ide. Her body will go through many changes such as puberty, pregnancy, and menopause. All of these changes are controlled by hormone levels.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

It is no wonder that a woman can be depressed easily. Add the daily stress of trying to be all things to all people and it is a miracle that

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

every woman that walks the face of this earth is not depressed.

There is also a definite genetic link in depression. If a family member has

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

been treated for depression, the odds of someone else in the same family developing depression will increase. There have been numerous studie

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s on twins and depression. The findings show that when one identical twin suffers from depression the other twin has a 50 to 90 percent chanc

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e of developing the disease also. This is true even if the twins were separated at birth and not raised together. Studies show that adopted c

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hildren whose biological parents had depression were three times as likely to develop the disease themselves.

There is a big difference in f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

eeling "blue" for a few days and actual clinical depression. Clinical depression lasts for weeks or months at a time and can get so bad that

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

it is disabling. People who have clinical depression can no longer enjoy any aspect of life. They can become so withdrawn and feel so worthle

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ss that suicide is the only way that they can perceive as a way out. When the depression is this severe, immediate treatment is vital.

No on

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e is immune to depression. It can strike any one at any time in their lives. But there is treatment for depression that can result in a full

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

recovery. If you feel that you might have clinical depression, see your doctor immediately. Don't let depression stop you from enjoying life

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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