E-Articles - Health and Fitness

A lot of our injuries happen when we are least expecting it. We might cut our finger while cutting the bread with a knife, or fall down the stairs because we get distracted by something, even almost lose our life because we cross the street without looking carefully befo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

re to see if there is a speeding car coming towards us. So, a series of disasters become part of a routine in our life. Depending on the severity of the consequences of our inattention, we may even laugh at our stupidity. We simply don’t pay attention to all these accid

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

nts if they happen only once in a while, and we believe we are normal people; we may not realize how often they actually occur. However, these accidents don’t happen by chance or only because we are distracted. Firstly, the fact that we are distracted when we should be

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

very careful, indicates that we don’t have the proper attitude towards serious matters.

Accidents can become a nightmare - they can turn into serious disasters. We better discover their hidden meanings, before they kill us! People that experience several accidents in t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

eir daily life shall not be considered “just a bit vague”. They suffer all the time with many accidents because they have a hidden suicidal tendency.

First of all, we have to consider the characteristics you have from the beginning of your life… Some people seem to ador

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

life. No matter how much they suffer, they are always laughing and trying to be happy. They are often superficial, and usually belong to the extroverted psychological type whose judgment is based on sensations. Other people seem to hate life. They are always afraid and

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

expecting the worst.

People have different psychological types, and each one of us has his own story, full of disappointments, wounds, bad memories, tragic facts and events, besides the joy of some moments and better periods of time. Each one of us has a world inside hi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

self, and a defined psychological type, that induces us to behave in a certain way, based on the psychological function we develop in our psychical sphere.

So, depending on which psychological type a person belongs to, they have a completely different reaction to the sa

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e stimulus. This reaction depends also on the personal psychical traumas they have had.

Some people that belong to introverted psychological types for example, are more vulnerable to acquiring a suicidal tendency.

When we see a person that has such a hidden tendency, w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e have to try to understand why they don’t want to live. Usually they are accepting living under unbearable conditions, or accepting horrible situations, without understanding they have to change and abandon this way of life. They can not accept what doesn’t make them ha

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

py without caring about their happiness, and they can not continue to ignore reality forever… There are many problems they may have in their daily life, perhaps during many years repeatedly, that are killing them softly inside. So, their hidden desire is to die, even tho

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

gh they know they can’t actually commit suicide. They don’t accept the idea of a suicide, because that’s what they have been taught. However, deep inside them, they only want to die and abandon forever all the horrors they have to swallow every day… all the problems they

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

know will never find a solution… everything!

This desire is condemned by their human conscience, that’s why is it hidden and appears in an obscured form: it seems to be only a tendency to be negligent. In fact what happens is that their psyche wishes to die, and they

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tart having strange thoughts, fantasising or dreaming about a sudden death, in which they wouldn’t be the ones that decided to abandon life, everyone and everything, in such a cowardly way.

They start accepting ideas like: “I could easily die if a very simple accident w

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uld happen now…”, and “it wouldn’t be my fault…” But these thoughts never create decisive action towards suicide, because their conscience is still alive and not allowing them to accept the act, while pretending they had only an accident.

We never know however who is go

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing to win in the end. Is the human being going to overcome his depression and become healthy and balanced, after winning the battle against the strong tendency to commit suicide, or is this strong tendency going to push him to really kill himself in this hidden way?

My

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

advice is to always consult a psychologist if we’ll observe that we suffer from several small accidents, or somebody else close to us does. The constant accidents are not the result of negligence. They reflect a suicidal tendency, without any doubt.

Perhaps the problem

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

an be solved if we pay attention to what is happening generally in our lives and do something courageous to change the awful situations in which we live, or abandon them. Perhaps the signs of a hidden suicidal tendency will open our eyes to reality and demand from us a s

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

erious response.

In the meantime, people that have this problem have to be always very careful, never doing things on a hurry. Until they’ve overcome their problem, they should do things very slowly and always pay attention to what they are doing. It’s better to miss th

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

bus, for example, than to miss a step and lose their lives. They have to allow more to go anywhere, because they can’t run. They are sick, and need to be very careful until they have overcome their depression - when this dangerous hidden suicidal tendency will disappear

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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