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Depression reflects the horrors that one passes through in their life, which makes us believe we can eliminate depression if we can eliminate all the horrors that exist on our planet. This is true up to a certain point, because if we can’t fight against the horror

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

s that exist in our environment, we can’t hope to have a healthy society. We can only ever have a depressed and sick society, where many individuals don’t have a chance of overcoming depression.

However, it’s an illusion to imagine that depression wouldn’t exist

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

in our society if conditions were better, because depression doesn’t depend only on external factors, but also on the function of each person’s psychical sphere.

A depressed person has to deal with a sort of insanity, because they are weak and vulnerable to all t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

he absurd thoughts and tendencies that already exist in their psychical sphere. There is a huge part of everybody’s psychical sphere that belongs to our wild conscience and sends us towards insanity... A depressed person can easily become crazy and abandon everyth

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ing, committing suicide.

We sometimes believe that there are logical reasons for a suicide, but there are only logical reasons for depression, not for the act of suicide. Suicide is an aggression against society. People that kill themselves also kill a part of al

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

l the people around them with their action. A suicide means terror for everyone near the suicider, because this person destroys the lives of those that depended on them. This is craziness! A suicide is never a logical solution, even though depression is a logical

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

consequence of all the terrible situations we face in our life, because it can sometimes seem that we live in a hell governed only by violence and hypocrisy.

A suicide is a very violent action, a crime against society, but it is also the reply of an individual th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

at feels he is society’s victim. It’s the way he finds to show his despair to the world - and the world has to be considered partly responsible for this tragic end, because this absurd world pushes everyone towards depression. So, the aggression made by the person

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

that commits suicide is also a protest against society’s cruelty.

A depressed person still has to fight against the suicidal tendency that provokes panic and despair, though. They definitely have a reason to be depressed – there are terrible things in the world

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

- but they have to resist reacting to depression’s impulses. Otherwise, they’ll lose control of their behaviour and perhaps commit suicide.

The cure for depression is resistance. A depressed person has to do everything a normal person does, without staying isolat

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ed, responding with apathy to any stimulation.

They need to be around people at all times, so that they’ll be protected from suicidal thoughts that become worse when the person is alone. They also need to work, keeping themselves busy for a fair amount of time, i

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n order to beat depression.

A depressed person only wants to die, not to do anything, not to go anywhere. So, by working they are fighting against the tendency to stay in a static condition where they are gradually dying. This is very hard! They have to fight aga

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

inst a very strong tendency to become a lifeless statue. They have to work and care about their appearance, to do everything a normal person does, despite their desire to do nothing, despite their fear and all the other symptoms they suffer from.

This is very imp

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ortant; it is the only way they can overcome their depression and be cured. If they abandon their efforts and simply let their disease dominate their behaviour, they’ll suffer forever.

We all live in a hell where infinite horrors frighten us constantly, but livin

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

g in a perfect world (which can’t be achieved only through political strategies, as many imagine) is not the solution for depression. A world with all the conditions for the development of everyone’s personality is more than necessary if we want to have psychical

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

health. But this is not enough! We need much more - a global psychotherapy. Depression is not only a result of pressure and despair, but also an internal disease that provokes many absurd reactions that spiral out of control and beyond normality.

That’s why a per

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

son has to try to be strong, keep busy and hold on in order to overcome the disease before it becomes too late. They have to behave like people that have a broken bone, and need physiotherapy in order to recuperate.

This is always hard, and in some cases really i

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

mpossible, but it has to be tried. The results are always positive, because if the person resists against all the disease’s attacks through all the symptoms it provokes, they will often start feeling better after the long fight. The symptoms become weaker, until t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

hey disappear.

Of course, everything is related: the environment, the person’s personal life and their psychical sphere’s functionality. There is no guarantee that a person will really overcome their depression if they’ll fight against its symptoms, because we do

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

n’t know if the person will bear being so resistant till the end. In some cases the person has no power to fight, because the disease already destroyed their human conscience.

For most cases however, resistance works like medicine and can really cure the disease!

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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