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Depression has always been a big taboo in most societies. There are a lot of people who feel they are suffering from depress

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ion but don't know what to do and where to get some help. Maybe it's time to get beyond stereotypes and taboos that prevent

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eople from treating depression and its symptoms effectively. Let's open our minds. This article will help you if you think y

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

u are suffering from depression, anxiety or stress.

- First, you need to talk to someone close to you. Your husband/wife or

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

your parents or your closest friend. Someone who cares will listen to what you have to say and you will get that feeling of

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

elief after discussing your issue. Talking works wonders.

- A lot of people confuse sadness with depression. Sadness is a b

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

t different. It is a natural reaction to the loss of something important. It is natural for us humans to experience periods

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

of sadness or grief or other depressive symptoms like eating or sleeping disorders. But these symptoms will not last long fo

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

most people. We all have bad days but we can always have a great day tomorrow. These temporary feelings are not depression.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

- Only if you have these depressive symptoms nearly every day for a period of 15 days you should ask for help. You have to

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

dentify your form of depression and your symptoms. You might need to see an expert and get a professional opinion. A well tr

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ined professional will determine if you suffer from clinical depression or if you are going through a blue period of sadness

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

If the psychotherapist diagnose depression he/she will initiate some kind of therapy (usually antidepressant therapy or psy

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

hotherapy). It's always a good idea to see a second expert and get a second opinion before going for any therapy involving c

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hemicals.

- Also, Try talking to other people who suffer from depression. Check if there are any hotlines in your area that

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

will get you connected with experts or patients or someone who can consult you on what to do. A good idea would be to take a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

walk/ride to the local hospital or health center and get their opinion as well.

- Will you accept the fact that you suffer

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rom depression? It's not easy to do it in our modern societies. A lot of people are ashamed of having depression. Others are

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

shocked. Well, it is important to know that you are not alone. Depression is common and it is also treatable. You just have

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o identify the form of depression you are suffering from and then decide which depression treatment/method will work for you

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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