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I heard about a woman who was suffering from depression, so her concerned husband took her to a psychiatrist. The doctor listened to the couple talk about their relationship, and then he said, "The treatment I prescribe is really quite simple." With that, he went over to the man's wife, gathered her up in his arms, and gave her a big kiss. He then stepped back and looked at the woman's glowing face and broad smile. Turning to the woman's husband, he said, "See! That's all she needs to put new life back into her." Expressionless, the husband said, "If you say so, Doc, I can brin

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

g her in on Tuesdays and Thursdays."

Okay, that’s not how to treat depression, but I have a few other suggestions that make more sense. As a result of trial and error, over the course of thirty years, I’ve found ten blues battling strategies that often help me. These are not quick fixes, and this list is not exhaustive. It is also not a "must do" list.

When you’re depressed, the last thing you need is a list of expectations to live up to. Don’t stress about forcing yourself to accomplish all these things. They’re not items to be checked off a list each day. The only one that

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

s crucial is number one. After that, you can experiment with the others as you feel able to.

1) Get the Facts and Get Help.

Web sites and books on depression abound. Find them and do some research. You need to know what you’re dealing with. Learn all you can about depression, so you can make educated decisions about your own health, learn how others cope, and find what medical treatment is available. Many books have self tests to help you determine whether you are experiencing clinical depression or temporary sadness in reaction to an event. In addition to reading everything

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

you can get your hands on, one of the most important things you can do for yourself is seek medical help right away. Depression is much too complicated for you to solve on your own. Clinical depression is a serious medical condition that is very complicated to treat. Often it is a physical problem that requires long term medication. In my own experience, it's taken years of medication, counseling, and practicing various self help methods to slowly emerge from it, and it's still a daily battle.

Many people suffer needlessly from depression because they won’t consult a doctor. I

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

you’re waiting for God to heal you, consider this: God gives scientists intelligence, which they often use to create helpful medicines; and He gives doctors wisdom to treat illnesses. Wise doctors and modern medicines are gifts from God and vehicles through which He often heals. Doctors can help you determine whether what you feel is truly depression, or if you are just reacting normally to a sad life situation.

If you’ve experienced depression, you already know it is not an illness you can "snap out of," no matter what others may tell you. It’s not something to be ashamed of

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

either. Depression can be a serious physical illness caused by an imbalance of brain chemicals or other factors. Like any serious medical condition, depression needs to be treated. Without the proper treatment, none of my suggested coping strategies will do any good.

2) Get Focused.

Feelings of hopelessness and helplessness pervade the life of a depressed person. The opposite of depression is a hopeful attitude. Focusing on hope and developing a hopeful heart is a must. One way to focus on hope is by practicing positive self talk. This simply means telling yourself good thin

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s. I made a list for myself of positive affirmations like "God cares and understands my pain. God values me. God is giving me strength. I can choose my attitude. I choose not to put myself down. I’m a worthwhile person. I have a purpose. I enjoy life. I choose to be happy and I am competent." If you struggle with depression, I think you’ll find it helpful to write down as many of these affirmations as you can think of and read them every day. Even if they’re not currently true or you don’t really believe them, it’s okay. Say them to yourself anyway. Your mind will come to belie

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ve what you tell it, so tell it you are already the type of person you want to become.

3) Get Friendly.

Fellowship with other people is a mood lifter. Being alone is the worst thing you can do when you’re depressed. Unfortunately, it’s usually the very thing I want most. Depression grows best in isolation. I find it very difficult to get out and socialize when I’m depressed, but if I push myself to do it, I’m almost always glad later. Some ideas for socializing include joining a club, taking a class, inviting someone to meet you for lunch, or visiting a nursing home to chat w

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

th the residents there. It especially helps me to be with friends who enjoy the same hobbies I do. Shopping, watching movies, and rubber stamping are some of the things I enjoy doing alone, but they’re twice as much fun when I do them with friends.

4) Get Giggling.

I collect cartoons and funny newspaper columns. I visit humor web sites online, watch funny movies, and read funny books. Best of all is laughing with friends. One of the reasons I enjoy my grandson so much is because he makes me laugh. I can act goofy with him and let go of my inhibitions. We dance and sing and ma

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ke up silly rhymes. I have photographs of us wearing funny glasses with big black mustaches. I laugh every time I look at those. Laughing affects brain chemicals. It releases endorphins, which make you feel good. Chocolate does the same thing, but a good laugh is less fattening.

A friend of mine, who had a very frustrating job, told me that one day she was inspired by someone who had a huge, bright smile. She decided to emulate that woman and smile at everyone she encountered. Right away, she realized that smiling was addictive. It seemed to make the time pass more quickly and

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

she found herself less frustrated and more at peace. She told me, "It sounds corny, but it really works!"

5) Get Rhythm.

When I feel a case of the gloomies descending, that is not the time to play melancholy music. Positive upbeat tunes are in order -- the sort of music you might hear at a parade or a circus. Music gets your toes tapping and your blood flowing. It makes you want to sing. Singing and dancing sends a message to your brain that you’re happy. Your brain is an actualizer. Whatever it "thinks" is true, it works to bring about. This is why positive thinking works. Y

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

u tell yourself, "I’m happy" often enough and your brain accepts it as fact. It actualizes that truth, making it happen. I’ve found that when depression takes hold of me, I tend to ruminate on negative thoughts. Listening to good music with positive lyrics helps to pour good things into my brain and crowd those negative things out.

6) Get Busy

We all need to feel like we’re involved in something significant. We need to participate in something outside ourselves. You might consider volunteering at a local women’s shelter or food pantry. I’ve enjoyed both and discovered that wh

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

en I stay busy helping others and concentrating on their problems, I get a break from focusing on my own troubles. This is how I created the HUGS and HOPE Foundation for Sick Children (www.hugsandhope.org). It started with a small effort to make a difference for one family and it grew. I’ve learned that joy boomerangs. When you give it away, it comes back to you. Helping others gives you the heart-warming satisfaction of knowing you are making a difference in the world. That will elevate your mood as well as your self esteem.

7) Get Physical

This is two-fold. Physical exercis

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

is good for us, but physical contact is equally important. Our bodies need to move to be healthy, and going for a walk is the easiest exercise for me to do when I’m depressed. It doesn’t require as much energy and motivation as other activities. Breathing the fresh air and looking at the beauty of nature can be helpful, and taking my dog along is even better. Just watching his ears flop as he bounces down the road in front of me often brings a smile to my face.

Exercise affects brain chemicals, and the healing touch of physical closeness does too. If you’re depressed, hug som

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ebody - anybody, everybody! A hug is good medicine. It reduces stress and tension and it boosts your immunity to illness. Hugs raise self esteem and lower blood pressure. They feel good and make people happy. And they’re free! Hugs are the universal language that communicates love and acceptance. They’re healthy for the "hugger" as well as the "hugee."

8) Get Quiet

Too much solitude can worsen depression. Isolating yourself and avoiding people can make depression grow. Meditation can be a good thing, but don't let it become an excuse to avoid human contact. Balance between qu

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

et time alone and time spent with others is essential.

9) Get Forgiveness – And Give it Too!

I’ve read that many psychiatrists agree that depression is guilt or anger turned inward. Depression can sometimes be caused from the need to forgive someone else or yourself (whomever is making you angry). Grudges cause feelings of frustration, which aggravate the hopeless feelings of depression. When we forgive, we let go of past hurts and give up bitterness. Then depression has no negativity on which to feed. If you free yourself from feelings of hate and open yourself up to feeling

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s of love, you may feel as if the depression is physically lifting off your shoulders.

My friend Nance went through a difficult divorce, which left her bitter about the past, anxious about the future, and miserable in general. She harbored a lot of grudges and guilt, and she worried constantly. She felt the need to control everything in her life, yet she knew she couldn’t. After attending a women’s retreat, Nance realized what her negativity was doing to her.She released her worries, fears, anger, and resentments at the foot of the cross. Then she felt a renewal in her heart.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

he was happy and at peace.

When she was dying, Nance told me that the most difficult thing she’d ever had to do was forgive – both her ex-husband and herself -- for past mistakes. She said forgiving was even harder than dying!

Forgiveness isn’t a simple one time event. It’s a process that often takes time (sometimes years), but it’s an important step to healing.

10) Get Thankful.

When I’m depressed, I need to make a conscious effort to count my blessings. An attitude of hopelessness and discontent has a hard time competing with an attitude of gratitude. It’s important to re

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

member that depression is not fatal and it doesn’t last forever. You WILL survive! Remind yourself that this cloud of despair will pass eventually. It may seem like there’s no light at the end of the tunnel, but trust that there is; and be thankful for that, as you wait for the light to appear.

So, while kisses from your husband (or a psychiatrist) may be great, they can’t cure depression. But along with medication and the proper treatment, now you have some practical steps you can take for your own well being. There are times when one of these strategies may be more helpful t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

an the rest. Other times, it may seem that none of them makes a huge difference. But I keep practicing all of them anyway, because I know they are steps toward a healthier lifestyle. Following them on a regular basis may not eliminate depression forever, but they help me to minimize their severity.

These tips can be helpful for people who are not depressed too. They can be useful for anyone who is a little discouraged, a little blue, or needs to refocus on more positive things in life.

I hope that by trying these ideas you may find yourself on the way to experiencing more joy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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