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According to Webster’s dictionary, holistic means: considering a whole thing or being

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

to be more than a collection of parts; Treating the whole person rather than just the S

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

mptoms of a disease.

Now, in terms of depression, this would mean that any methods

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

of dealing with depression being used, would be targeted and not just the symptoms of de

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ression such as inexplicable sadness, changes in moods etc, but the causes, effects and

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ther aspects of the patient’s experiences.

In this day and age when several people are

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

in need of some form of depression treatment help, it is no wonder that such an approach

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

is becoming more popular by the day.

At the moment, it might be safe to say that althou

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

h holistic treatment for depression takes an enormous number of treatment modalities, th

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e FDA and the medical institution often have a tendency to hold back and disregard alter

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ative medicine as a feasible option.

They tend to believe that there is insufficient ba

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

king to show the efficacy of such an approach, however, this should raise some concern a

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s a lot of the required drug studies that are written are done through the same drug com

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

anies that produce them.

But, in spite of this, I must stress that people should not bl

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ndly accept the claims of alternative medicine either

Nonetheless, it is still safe to

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

say that in general, alternative medicine or Holistic treatment for depression methods c

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

n be much safer than conventional drugs when one weighs the side effects of the use of t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

e latter option.

Perhaps one thing that remains to be said is that if you’re suffering

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

from depression, one of the first steps to overcoming it may lie in getting some help an

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the options are indeed plentiful.

All in all, here’s to happiness.

In Friendship,

Aj

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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