E-Articles - Health and Fitness

What Causes Depression?

Depression is a complex illness that affects up to 10% of the population at any given time. While we did not have too much insight into the problem at the

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

beginning of the 20th century, medical research has enabled us to learn quite a lot in recent years. However, scientists, doctors and researchers have so far been unsuccessful in

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

pinning down one specific trigger for depression.

The current line of research is that depression is probably not caused by any single element, as was believed earlier. That belie

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

generated from the fact that all other diseases encountered till then had one single source. Now, however, researchers are beginning to believe that there could be multiple trigge

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s for depression, all of which vary from person to person and manifest in different ways.

Researchers have identified three such elements that they believe are the vital triggers

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

or depression. These are:

· Biological
· Environmental
· Genetic factors

Any combination of the above mentioned factors could also cause depression.

Biological Ele

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ments Causing Depression

As the term indicates, biological elements relate to basic biological changes in the body. These changes can be of many types. Onset of a severe illness c

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

uld trigger a bout of depression. Another such trigger for depression could be some form of medication that a person is taking, or any form of substance abuse, be it alcohol or nar

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

otics or medicines.

However, biological causes are primarily related to chemical changes within the brain. A chemical imbalance in the brain can, for example, trigger severe depre

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

sion. The most common such imbalance is that seen in neurotransmitters. Neurotransmitters facilitate the communication between brain cells, as the name suggests. An imbalance in se

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

otonin and norepinephrine, two neurotransmitters, is seen as the most common link to depression due to biological elements. Imbalances in other chemical elements within the body ca

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

n also cause depression.

Environmental Elements Causing Depression

Environmental elements relate to changes in a person's immediate environment, be it physical or mental. Radical

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

changes, trauma and instability have a significant role on the human psyche. Harmful environmental factors include traumatic childhoods, high levels of stress at work or at home, t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

e trauma caused by the breakdown of a relationship, etc.

Environmental instability can lead to emotional instability, which in turn will result in a greater likelihood of depressi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

n.

Genetic Elements Causing Depression

The genetic elements are now the ones that are being most scrutinized. Recent research, especially from the latter half of the 20th century

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

onwards, has shown that genetics has a large role in most of the issues, both positive as well as negative, related to human beings. The answers to most complex and so far unanswer

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ed questions lie in the genetic makeup of the human body, according to many researchers. This applies to depression as well.

Researchers have discovered that family history plays

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

large role in determining if a person would show a higher tendency towards depression. Other findings have shown that if a family member suffers from clinical depression, you will

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

be 1.5 to 3 times more likely to develop the illness as well.

Depression, like almost any other illness, is the result of a number of influences. Age, genes, environmental and psy

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

hological factors all play a role in human development. It's important to know the causes because the more you know, the better equipped you will be to help yourself or a loved one

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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