E-Articles - Health and Fitness

Depression in people more than 65 years old is very common. If this condition goes untreated, it often results in suicide. The problem with most people who are in contact with these

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

elders is that they tend to overlook the signs and symptoms. Depression in the elderly can have many possible causes. They could be anything from the physical, to the psychological

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and even to the environment. It can either be genetic or just part of one's personality. Whatever the cause, they would exhibit similar giveaway signs that indicate that they are d

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

epressed. These signs should be observed carefully to facilitate intervention.

There have been studies that note that depression has a tendency to be inherited. It could also be ca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

used by changes in the vascular network of the brain and different illnesses seen in old age such as Parkinson's disease, Alzheimer's disease, stroke, or cancer. Conditions such as t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ese may have chronic or severe pain that may trigger and sustain depression. As a person grows old, he encounters many changes in himself and in the environment such as damage to his

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

body image, frustration experienced with memory loss and other motor and sensory dysfunctions, fear of nearing death and loss of loved ones. The elderly often have difficulty adjust

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ing to these changes. Depression may also be due to repressed or suppressed traumatic experiences that were left unresolved as a child because these tend to resurface as the individu

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

al slows down later in life.

A big part of the aging population suffers from some kind of physical condition and therefore takes medication for it. These drugs may be needed to main

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

tain normal daily functioning however, some of these meds may have side effects that could cause or worsen depression. There are some medicines for pain relief, for lowering blood pr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ssure and for controlling anxiety that have depression as a common side effect. Other drugs that have this effect are heart medications, hormones, anticancer agents, antipsychotic ag

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ents, medication for the control of Parkinson's disease and for arthritis. There are drugs, even when combined, which have no unpleasant effects. However some drugs, when taken toge

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ther and are allowed to interact, can result in adverse effects. To avoid these non-therapeutic outcomes, physicians should be aware of the different types, dosages and drug interact

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ions of the medications the patient takes and discuss with their clients the importance of strict compliance to the treatment regimen. Treating depression using antidepressants somet

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

imes is not the best approach because there is a high risk for unfavorable drug interactions. Elders taking antidepressants should be closely monitored for changes. Also, some antid

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

pressant medications create dependencies. Depression is closely associated to the abuse of prescription drugs or alcohol and is quite common in the elderly.

Depression can also be d

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

eeply rooted in the personality structure of a person especially when he has some unresolved issues or trauma from early life. Also, when a person already has low self-esteem, is unc

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

onfident and generally has a negative outlook on life, it is not surprising that he will be depressed. In addition, depression is recurring. It occurs much more in elders with a his

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tory of depression. Depression usually would set in when the person is deprived of sufficient emotional and psychological support or is not psychologically ready to encounter life ch

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

anges like retirement, disability, being unmarried, loss and bereavement. In these times of crisis, the person feels alone, unwanted and isolated and needs much attention and support

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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