E-Articles - Health and Fitness

People more commonly associate depression with adults rather than with the younger generation. Recent studies, however, show alarming statistics on teenage suicide as a result of depression: Suicide is the eighth leading ca

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

use of death for all persons regardless of age, sex or race; the third leading cause of death for young people aged 15 to 24; and the fourth leading cause of death for persons between the ages of 10 and 14. Depression now o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

curs in about 5% of adolescents at any given point in time and often without parents even knowing about it. According to a recent survey of high school students, teens (60%) often think about killing themselves and some (9%

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

) say they have made an attempt at least once. In the past three decades, teen suicide worldwide has risen up to 300%.

What is teenage depression like and when should parents be concerned?

While it is normal for everyone,

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

not just teenagers, to feel the ‘blues’ occasionally, depression becomes an illness when the feelings of dejection, hopelessness, and despair persist and interfere with a person’s ability to function. Depression is often ac

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

companied by feelings of helplessness, being overwhelmed by circumstances, withdrawal and isolation. People suffering from depression are often prone to lethargy, overeating or loss of appetite, worry, moodiness, withdrawal

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

from family and friends, and lapse into inactivity.

What causes teenage depression?

Depression can be caused by any single or combination of biological, psychological and social factors. Biological factors that play a ro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

le in depression include infections, endocrinal problems, hormonal imbalances, hypoglycemia, exposure to toxic substances, improper diet, anemia, and even certain medications. Psychological causes involve elements that pred

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

spose people to become depressed as a result of their unhealthy self-esteem and negative attitude towards others, the world around them, and the future. Pressures in life are also often at the root of depression problems, a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

mong them failure, frustration, and experiences of loss (death of a loved one, divorce, relocation, break-up with steady girl/boyfriend, etc.).

How can I deal with depression?

Aside from seeking professional/medical help,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

there are a number of simple but effective things that could relieve your persistent “blues”:

Pray consistently to God. If you must have a really good cry, cry to God—He listens and cares. He promises to deal with your pro

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

blems if you bring them to Him. Reading the Bible will be a great help—not only does it provide solid comfort but also practical wisdom for your issues. (1Pe 5:7; Php 4:6,7; Isa 41:10; Je 29:11-13; Heb 4:15,16)

Don’t keep

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

t to yourself. Telling someone you trust or respect about the problem is usually helpful. Reach out to others—studies show depressed people tend to feel less sorry for themselves when they comfort others who suffer from gri

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ef and tragedy. (Pr 12:25; 17:17)

Steer clear from idleness—an idle mind is fertile ground for depressing thoughts. Being busy and active are good antidotes to gloominess and divert one from entertaining negative thinking.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Win the battle of the mind. If your depression stems from seeking others’ approval for your happiness, consider that it is not healthy to always leave it up to them to measure your sense of worth. If the problem lies in si

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n or guilt, remember that God’s forgiveness is always readily available to those who sincerely ask for it; but do not forget to do what it takes to get your life right with God . If the source of depression is failure, exam

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ne your goals and set realistic ones, asking God to help you achieve them. Accept the fact that disappointments are a part of life. Choose to ‘get over it’ rather than feeling stranded in hopelessness and uselessness. Surro

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

und yourself with positive things and positive people. (Isa 1:18; Pr 28:13; Ps 103:8-14; Php 4:8-9; 1Jn 1:9)

Eat sensibly and get enough sleep.

Exercise to perk up your mood. It increases the neurotransmitter serotonin (h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ppy chemicals), the levels of which are significantly low in depressed people.

Use humor. Laughter also induces the production of ‘happy chemicals’ in the body and promotes overall wellbeing.

Avoid smoking, alcohol, marij

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

uana and sedatives generally. While these seem to make things better in the short-term, they could adversely affect your health and make depression worse. Drugs and medicines are best administered with the doctor’s guidance

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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