E-Articles - Health and Fitness

Diabetes is a disease wherein the body is not able to produce, or cannot properly utilize the hormone called insulin. Insulin is needed by the body

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

to convert starch, sugar, and other food into energy as needed for life’s daily activities.

Diabetes is a big health concern, and for some, will eve

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

n prove to be fatal. The diabetic symptoms are very common, and may not seem harmful at all. This lack of concern for what seem like minor symptoms

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

may lead the disease to to undiagnosed.

To further understand the disease and what its tell-tale signs are, here is the list along with a brief exp

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lanation of each:

Frequent Urination - A person with diabetes will notice that they need to go to the restroom quite often. Frequently enough so as

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

not to be normal. On average, a person may use the bathroom 3 to 6 times a day. A greater frequency that remains consistent for any length of time,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

should be spoken about with a doctor.

Excessive Thirst - If your need for water, or any other drink, exceeds what is normally considered necessary

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

for you, this may be a diabetic symptom.

Extreme Hunger - Just like extreme thirst, a person with diabetes may also feel extreme hunger. They might

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

even feel hungry right after having a good, hearty meal. Should you feel this way more than once a day, monitor yourself for a week or so. You mig

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ht have diabetes and not know it.

Unusual Weight Loss - If you are not dieting, or cutting back on your meals, but are losing a considerable amount

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

f weight, there could be a problem. Try to monitor the food you eat and the exercise you do each day, if applicable. It should be proportional to t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

he weight you lose. Otherwise, you might need to visit your doctor as this could be a diabetic symptom.

Increased Fatigue - The feeling of tiredness

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

is very apparent for a person with diabetes. There could even be instances where they would become very tired even after minimal activity. More s

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

o, should the activity be a strenuous one. Do not assume that it is just your age or that you are not in good shape. Better to check with your phys

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ician as to the cause.

Irritability - A person with diabetes may grow more irritable by the minute. This is due to the feeling of something unsettl

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

d in the body that they can’t quite recognize. Being irritable is not always a mental state. It can be physical as well.

Blurry Vision - Blurry vi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

sion may be attributed to many factors, not only diabetes. But, should you feel that your eyes are becoming weaker by the minute, coupled with one o

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

r two of the above mentioned symptoms, and your blurred vision may in fact be a diabetic symptom. The only way to be sure is to visit your physician

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

.

Diabetes is referred to as a silent killer. The reason for this is quite simple. The diabetic symptoms listed here are so ordinary you won’t thi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nk that you may have diabetes. So, the lesson here is; do not take even the most common symptom for granted. It may very well be a diabetic symptom

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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