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Diabetes Mellitus is one of the most costly burdensome chronic diseases of our time and is condition that is increasing in epidemic population in the whole world. The complications resulting from the diseases are a significant cause of morbidity and mortality and are

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

associated with failure of various organs such as the eyes, kidneys and nerves. Diabetics are also at a significantly higher risk for coronary artery disease, peripheral vascular disease and stroke and they have a greater likelihood of having hypertension dyslipidemia

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and obesity.

What is Diabetes?

Diabetes is a serious disorder of the glands, of pancreas to be exact, called Madhumeha in Ayurveda. It is one of the most insidious disorders of the metabolism and, if left undiagnosed, may lead to rapid emaciation and ultimately dea

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

th.

What are the types of Diabetes?

According to Ayurveda Diabetes is of two types: Diabetes Mellitus- Insulin dependent Juvenile Diabetes (IDDM-Type I) in which the body is unable to produce insulin and Non Insulin Dependent Adult Onset Diabetes (NIDDM-Type II) in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hich the pancreas produces insulin, but it is insufficient for reducing the blood glucose to normal levels.

What are the common symptoms of Type- 1 Diabetes?

Some of the common symptoms of Type- 1 Diabetes are:

Excessive Thirst
Frequent urination

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro
i>Unexplained weight loss
Irritability
Weakness
Fatigue

What are the common symptoms of Type- 2 Diabetes?

Some of the common symptoms of Type- 2 Diabetes are:

Loss off weight
Numbness in hands or feet.
Uncontrolled infectio

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

Pain in the limbs

Inflammatory chest infections

Dimness of vision, contrast

Excessive thirst

Body weakness

What are the different tests for Diabetes?

Urine Test: Some chemicals are added to a few drops of urine. Colour change indic

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

tes presence of glucose in urine.

Blood Test: In this, blood is taken to test the glucose level. This is more accurate test to confirm diabetes

Which parts of my body are affected by Diabetes?

Blood Vessels: Higher level of glucose damage the blood vessels. As a re

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

sult of this most of the diabetic complications occur in blood vessels.

Heart: Diabetes affects the heart by: Increasing the amount of fat in blood and increasing the amount of homocysteine in blood.

Kidney: In diabetes because of increased levels of glucose, kidney

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s have to do extra work to retain essential substances and separate waste products to produce urine. This affects the small blood vessels and their capacity to filter. After many years of work, it leads to kidney failure.

Eyes: Diabetes affects blood vessels of the e

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es. Damage to these blood vessels leads to eye problems like: Damage to retina, Cataract or total loss of vision

Foot: Damage to blood vessels reduces blood flow to the feet and increases risk of developing foot ulcers and infections.

Nerves: High glucose level for

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

a long time damages nerves. Nerve damage reduces sensation in some parts of body which may lead to: Numbness and tingling, Fainting and dizziness

How do I know if my diabetes medicines are working?

Learn to test your blood glucose. Ask your doctor about the best tes

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ting tools for you and how often to test. After you test your blood glucose, write down your blood glucose test results. Then ask your doctor teacher if your diabetes medicines are working. A good blood glucose reading before meals is between 70 and 140 mg/dL.

Ask yo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ur doctor about how low or how high your blood glucose should get before you take action. For many people, blood glucose is too low below 70 mg/dL and too high above 240 mg/dL.

One other number to know is the result of a blood test your doctor does called the A1C. It

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

shows your blood glucose control during the past 2 to 3 months. For most people, the target for A1C is less than 7 percent.

Home Remedies for Diabetes:

The best remedy for this disease is the bitter gourd, better known as ‘karela’. Eat this vegetable as often as you

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

can or have at least one tablespoon of karela juice daily to reduce blood sugar levels in your blood and urine.

Amla, due to its vitamin C content is effective in controlling diabetes. A tablespoon of its juice, mixed with a cup of fresh bitter-gourd juice, taken da

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ily for two months will secrete the pancreas and enable it to secrete insulin.

Take ten tulsi leaves, ten neem leaves and ten belpatras with a glass of water early morning on an empty stomach. It will work wonders in keeping your sugar levels under control.

The leav

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s of Butea tree are very useful in diabetes. They reduce blood sugar and are useful in glycousia.

Take two teaspoons of powdered Fenugreek seeds with milk. Two teaspoons of the seeds can also be swallowed whole, daily.

Eat 10 fresh fully grown curry leaves every mor

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ning for three months. It prevent diabetes due to heredity factors. It also cures diabetes due to obesity.

More on http://www.ayurvediccure.com/diabetes.htm

*100% safe and Natural Ayurvedic Medici

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nes for Arthritis, Gout, Weight Control, Diabetes, Heart, Vigour and Vitality, Menstruation, Skin Care... made from Traditional Ayurvedic Herbs. Ayurveda, Diet Chart, Home Remedies, Massage, Naturopathy, Tips, Beauty and Skin Care.. Online Consultation, Books, CD/DVDs

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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