E-Articles - Health and Fitness

Gum disease, also called periodontal disease, is brought about by plaque, which is a sticky film of b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

acteria that continuously forms on the teeth and gradually destroys the tissues that surround and sup

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

port the teeth.

Prevention of gum disease involves methods to control and prevent the amount of tart

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r and plaque build-up on the teeth. These steps include proper dental hygiene, good nutrition, health

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y lifestyle choices and regular visits to the dentist.

Proper Dental hygiene: Brushing your teeth we

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ll at least twice a day, helps keep plaque and tartar build-up at bay. You should preferably use soft

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

bristled toothbrushes as they are less abrasive and make sure the bristles are in good condition. Mak

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e it a habit to change your toothbrush every three months. Inter-dental brushes and dental floss hel

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

p remove food particles from under the gum line, between the teeth and other places that regular toot

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

brushes cannot reach. Use a toothpaste and mouth wash that contains fluoride as it helps prevent deca

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

y and strengthen teeth.

Good nutrition: Eating a wide variety of foods from the different food group

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

s, such fresh fruits and vegetables, dairy products, poultry, meat, fish, cereals and grain will ensu

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e your teeth and gums stay healthy.

Healthy lifestyle choices: Starches as well as sugary foods and

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

drinks cause more harm to the teeth when they are eaten in-between meals. Also foods that stick to yo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ur teeth or tend to stay in the mouth for a longer period of time, such as jellybeans, caramels, mint

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

and hard candies cause prolonged and continuous attacks on the teeth and should be avoided.

Regular

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

visits to the dentist: Dentists and dental hygienists are vital in helping prevent any kind of denta

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

l decay or gum erosion. Regular check-ups stop tooth and gum decay from progressing further. The dent

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

st can offer helpful advice depending on the health of your teeth and gums. Scaling and polishing of

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the teeth can help remove tartar that is hardened and cannot be removed by mere brushing and flossing

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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