E-Articles - Health and Fitness

Malaria is a serious disease caused by a parasite. Infected mosquitoes spread it. Malaria is very common throughout the world. In the United

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

States, the main risk is to persons traveling to tropical and subtropical countries where malaria is a problem. There are four different ty

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

pes of malaria caused by four related parasites. The most deadly type occurs in Africa south of the Sahara Desert. The symptoms characterist

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ic of malaria include fever, chills, muscle aches, and headache. Cycles of chills, fever, and sweating that recur every 1, 2 or 3 days are t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ypical. There can sometimes be vomiting, diarrhoea, coughing and yellowing (jaundice) of the skin and whites of the eyes. The treatment for

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

alaria depends upon the geographic area where a person has been infected with the disease. Different areas of the world have malaria types t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

hat are resistant to certain medications.

Malaria is a disease which can be transmitted to people of all ages. It is caused by parasites of

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the species Plasmodium that are spread from person to person through the bites of infected mosquitoes. Malaria is a parasitic disease that

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

involves infection of the red blood cells. Of the four types of malaria, the most serious type is falciparum malaria, which can be life-thre

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

atening. The other three types of malaria (vivax, malariae, and ovale) are generally less serious and are not life-threatening. The scientif

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

c name of the particular type of mosquito is Anopheles. An infected Anopheles mosquito bites a person and injects the malaria parasites into

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

the blood. The malaria parasites then travel through the bloodstream to the liver and eventually infect the red blood cells.

Causes of Mal

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

aria

1. Malaria is usually caused by a mosquito bite and the parasite microbe is passed from the mosquito to the blood through a sharp hypo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

derme needle like sting. Risk factors include traveling in areas in which such mosquitoes are found or, rarely, being bitten by a mosquito t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

hat has previously fed on an "imported" case of malaria (such that the case can occur in an area of the world where malaria is not endemic).

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

2. Transmitted by transfusion of infected blood.

Symptoms of Malaria

1. Sequential chills, fever, and sweating.

2. Jaundice.

3. Stools,

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

bloody.

4. Muscle pain.

5. Anemia.

6. Headache.

7. Nausea and vomiting.

Treatment of Malaria

Prevention of malaria what is practiced

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

in epidemic areas is by spraying insecticides like DDT. Many new drugs are available for malaria, however most of the drugs are derived from

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Quinine derivatives. Malaria often requires treatment with medicine (antimalarial medications). Most of the time antimalarial medications e

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ffectively treat the infection; however, some malaria parasites may survive because they are in the liver or are resistant to the medication

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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