E-Articles - Health and Fitness

Do you run to the bathroom and nothing happens even though you have an uncontrollable urge to go to the bathroom? Do you have a sudden urge to go to

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the bathroom but have trouble making it in time? Do you go to the bathroom very frequently, more then 8 times a day with in a 24 hour period? Or d

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

o you plan your day around going to the bathroom? Well if you have answered yes to any of these questions then you could be suffering from a conditi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

on called overactive bladder.

An overactive bladder is not a natural part of the ageing process. It is not caused by drinking an excessive about of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

fluids. It is not caused by an infection but the symptoms may be similar. Usually it is not something you should have to deal with. A tip to your

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

healthcare provider is required to rule out any more serious problems prior to starting any type of home remedy.

When the bladder becomes full the

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

brain signals the muscles in the bladder to contact causing urine to exit the body through the urethra. Normally this is under voluntary control. H

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

wever for someone suffering from an overactive bladder the bladder can contract without warning causing frequent, sudden, and strong urges. Leakage

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

is a common result.

The following can cause an overactive bladder:

Surgery can damage the nerves controlling the urinary track or weaken the muscle

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s, thus causing involuntary contractions and making it harder to control the bladder.

Some medication such as sedatives, narcotics, and diuretics ca

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

n have a detrimental effect in controlling your urinary system.

Chronic illness or conditions like multiple sclerosis, diabetes, stroke, Parkinson d

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

isease and even obesity can cause you to suffer from an overactive bladder.

Treatments for overactive bladder include drugs like VESIcare and Enable

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

x can help by targeting the nerves or muscles that control the bladder thus helping to restore control of urination.

The Kegel exercise is a daily e

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

xercising of the pelvic muscles that is particularly helpful for younger women. If performed regularly the pelvic muscles can be strengthen enough t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

improve and even prevent urinary incontinence.

Good results are also found with vaginal weight training. Small weights are held in the vagina by t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ightening the vaginal muscles resulting in stronger muscle control.

The pelvic floor muscle tone can be improved with a mild electrical shock to sti

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

mulate the muscle contractions. This is similar to the Electronic Muscle Stimulator Machines used by physical therapist.

Behavioral therapies will

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

help people gain control of their bladder by teaching people to resist the urge to go to the bathroom for longer and longer periods of time. Using a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

set schedule to use the bathroom is also a major part of behavioral therapy.

Biofeedback helps people gain awareness and control of their pelvic mu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

scles.

Always consult your doctor before using this information.

This Article is nutritional in nature and is not to be construed as medical advice

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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