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Hypertension treatment can take many forms and medication is not the only option. Some patients may even resort to herbal remedies and treatments such as raw garlic. A qual

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ified doctor, however, will be able to provide you with a range of safe and successful hypertension treatments. When deciding upon a treatment, it’s important to consider th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

patient history and the fact that not all medications are a good fit and therefore not a default for all hypertensive patients.

When a patient is diagnosed with initial St

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

age 1 hypertension; diuretics form the frontline of the hypertension treatment protocol. Diuretics are a medication type that seeks to remove any excess water of salt from t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e relevant organ, the kidneys. There are three separate forms of Diuretics used in therapy:

• Thiazide Diuretics – Work by promoting heavy water excretion through the ki

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

neys and are usually used as a long term treatment to hypertension.

• Potassium Sparring Diuretics – Work by maintaining a level of potassium in the blood which caus

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

es large amounts of liquid to be drawn from the kidneys.

• Loop Diuretics – Act in a similar fashion to Thiazide’s and extract a huge amount of water and sodium from

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the kidneys. This hypertension treatment is often used during an emergency due to its effectiveness. Loop diuretics are also used when thiazide’s lose their effectiveness.
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
>

Angiotensin-Receptor Blockers is also a fairly new form of hypertension treatment. ARB’s mode of action will differ slightly from the above treatments by targeting the bl
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
ood vessels for an increased blood flow. ARB’s act by opening up or dilating the major blood vessels which in turn allows a greater flow of blood through them. This in turn
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
ssists the heart in the pumping of essential blood around the body hence resulting in a lower blood pressure. ARB’s are also rumored to reduce the risk of myocardial infarct
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a
on and congestive heart failure. The medications of choice for ARB’s are, Irbesartin, Losartin and Valsartin.

ACE inhibitors are quite similar to ARB’s, in fact, ARB’s are
dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod
derived from ACE inhibitors and both have a good treatment protocol. Both medications are extremely successful in hypertension treatment and are beneficial to patients in a
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
eart disesase risk category. Common ACE inhibitor drugs include: Captropril, Enalapril, Benazepril, Fosinopril and Trandolapril.

Beta Blockers are also a successful treatme
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
t option of hypertension sufferers. This form of hypertension medication achieves its reduction of blood pressure by reducing the heart pumping or contraction strength which
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
in turn reduces the pressure of the blood pumping through the arteries. Beta-Blockers are generally world renowned due to the fact that they increase the life expectancy of
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
the heart. The commonly available medications are: Atenolol, Carvedilol, Timolol, Bisprolol, Metroprolol.

Similar to Beta Blockers, Calcium channel blockers also work by de
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
reasing the hearts contractions but they also decrease the force of blood entering the arterial system. Often this process is referred to as dilation and is an extremely eff
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ective form of hypertension treatment.

These days hypertension treatments are varied and numerous and really depend upon the background and risk factors of the patient. Unf
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
rtunately, there are still difficulties with treating the disease and further research and drug development will be required to stay at the cutting edge of treatment options

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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