E-Articles - Health and Fitness

There is a very long-standing liaison between human beings and virus that wander unreservedly in our environment. Virus has a long history of disconcerting people.

A virus is a microorganism that is not vi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sible to the naked eye. It is highly contagious and communicable. A virus attacks and clips to a living cell of the human body. It then discharges its DNA or RNA, which smashes the original genetic material

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

and functioning of the cell. But before the victimized cell expires, it leaves or releases more of that virus. The virus multiplied in such a fashion impedes the growth and working of other healthy cells to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

, so much so that sooner or later the entire body comes in its grips. However, the immune system of the body endeavors its best to brawl the viral attack. But it does not succeed in all the cases. Due to th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

is reason, the doctors and dieticians prescribe a healthy diet rich in nutrition that strengthens the resistance of the body.

The Residence and Transmission of Virus- there are different types of viruses k

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

own. Some infect humans, others animals and a few affect both. Viruses are everywhere in our surroundings. They can be transmitted via the food we eat, air we breathe, water we drink, sexual contact etc.

S

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

me common Viral Infections- there are some well known viruses and the diseases caused by them.

· HIV virus is one that destroys the cells in the immune system of our body. It is therefore named as HIV i.e.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Human Immunodeficiency Virus. HIV takes the form of AIDS at an advanced later stage. HIV virus reaches the human body through several ways such as- via sex with a partner who is already living with HIV, th

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ugh infected mother’s milk to her child, through human saliva, HIV contaminated needles, syringes and so forth.

Thus, one should be very cautious regarding all these factors. Completely safety should be ob

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

erved to avert lifelong HIV infection especially because no adequate cure is yet available to eliminate the effect of HIV.

· Hepatitis is even caused by virus. Since different kinds of viruses are at work,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

there are different types of hepatitis. These viruses harm the human liver, which results in its burning or inflammation.

Hepatitis A and E spread via the food and water of the infected person and through

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

anal sex. There exists a vaccine for hepatitis A but not for E. Hepatitis B is caused by unprotected sex, childbirth and contact with infected person. Vaccination is available for hepatitis B and it is bett

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

r nowadays to get vaccinated against it. This sterilization also ceases the threat to be caught by hepatitis D in future. Hepatitis C virus is transferred by the way of contaminated blood and is cured throu

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

h medicines.

A possible prevention to hepatitis is to maintain hygiene and vigilance in matters of sex and contacts with other persons.

· West Nile Virus is known for causing diseases in animals, birds as

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

well as humans. In humans the WNV reaches through the bite of an infected mosquito. Once the virus enters an individual’s blood, it can get transferred to all those who come in contact with it though blood

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

transfusions, organ transplants, breastfeed and so forth.

In order to prevent oneself from the WNV, check the population of mosquitoes in your area and near your house. Don’t allow water logging, open bins

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

unhygienic sanitation, open pits etc. in your vicinity . Medication through drugs and no vaccination per se is present for WNV.

· Mostly the Asian and African continents encounter the threat of Polio Vi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rus. This virus can result in a minor to complete paralysis. The poliovirus can infect person of any age. Due to the lack of hygiene this virus comes in the air through human feces and gets circulated. It e

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ters the human body through his mouth and makes its way to the intestines. This virus particularly damages the legs of the person. The paralysis in legs due to poliovirus cannot be cured. It also destroys t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e respiratory system by making the breathing muscles immobile.

Most often polio hits the infants. Polio drops and vaccines are available everywhere. People should take them and give these to their kids too

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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