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Anorexia nervosa is an illness that affects mostly teenage girls, but cases of anorexia have been encountered at elder women and men also. In s

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hort words, those with anorexia intentionally starve themselves in order to lose weight, and the main problem is that they continue to starve t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hemselves even after losing a lot of weight, which greatly endangers their health and can lead them to die of starvation eventually, if they ar

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e not stopped.

It usually begins in the puberty, and its main cause is nervous-based. Modern society's beauty standards consider slim to be be

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

utiful and many people think fat is ugly and disgusting, so girls try to do anything they can to be as slim as possible, and they take this obs

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ession too far. Although the hunger causes them pain and suffering , those with anorexia pretend that they are not hungry and they do everythin

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

g they can to get more and more thin. Their image of their own body becomes distorted and they see themselves as fat all the time.

Anorexia ca

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n threaten the life if starvation continues for a longer period. It can seriously affect the heart and heart rate and lead to heart failure, or

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

it can cause osteoporosis to appear because the bones can be weakened if they are not supplied with the minerals that they need. In the women's

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

case anorexia leads to amenorrhoea, and in men's case to the loss of potency. Furthermore, in some cases it can also affect the temporal lobe

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of the brain, which starts to malfunction if the body does not gain enough minerals.

In order to help those with anorexia you must first disc

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

over that they suffer from it. Since their own image over their bodies is distorted they are not aware that they have an illness that needs to

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e treated, and they will refuse to belive it if you tell them. Those with anorexia nervosa can be spotted by the following symptoms:

-they are

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

obsessed with losing weight, they talk about diets and losing weight all the time

-they refuse to eat a meal when you offer them one, by maki

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ng up fake reasons such as they are not hungry or they just ate

-even though they are very slim they continue to do a lot of physical exercise

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

and try to lose more weight

-some of them can go further, and each time they eat they force themselves to vomit right after, or they overuse

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

axatives to empty their stomach

The treatment for those with anorexia consists in making them gain weight and eat so they can re-establish the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

body's balance. Most of them refuse to admit they have a problem so they must be forced to do it. Besides this, psychiatric treatment is neede

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d, in order to make the patients realize that they have a problem and that in fact it's all in their head that they are not thin enough.

There

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

are many non-profit organizations designed to help those with anorexia overcome their problem, so seeking help from one of them is recommended

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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