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Bulimia was first diagnosed only in the 1980s. The word Bulimia, which is Latin or Boulimia, which is Greek, means extreme hunger.

In this eating disorder, the individual b

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

inges and then purges which can be in the form of vomiting, exercising to excess or using laxatives or enemas, in order to try and get rid of the excess calories. This takes

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

place in a cycle of binging and purging. It is considered to be a psychological condition related to insecurity, depression, self-esteem or anxiety and not a response to hun

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

er. During these binging/purging cycles, the individual has no control over the situation. This is followed by a sense of calmness then followed by a sense of self-loathing

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

The binging varies from individual to individual; in one person a binge may be considered to be the consumption of even a small toffee whilst in another person it may be a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hole meal with a calorie value of anything from about 1000 to 20000 calories.

This is an eating disorder found very commonly in girls in their late teens and early adulthood

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

. However, it does affect all types of individuals, even older women. Men do suffer from bulimia but very rarely. In this condition, the individual may even steal food or

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ven eat from dustbins in order to satisfy the compulsion. They are aware of what they are doing and sometimes feel ashamed of it, very often therefore these binges occur in

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ecret. Hence it is very difficult to say if a person is suffering from Bulimia and also most bulimics look either of normal weight or sometimes a little overweight.

In buli

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ics, the only source of comfort is food. However, sufferers of bulimia often realize they have a problem and generally would seek help for it.

Causes of bulimia

There is n

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

exact known cause of bulimia. However, it is supposed to be as a result of a person not being satisfied with his/her body shape. It is also said to be a genetic problem.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Individuals who also suffer from low self-esteem and fear becoming fat, tend to become bulimic. It is more to do with psychological issues rather than issues concerned with

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ood.

Some other causes may be:

. In people who have problems showing anger, or have a difficult time coping with impulsive behavior. . Women from a particular culture

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

re under pressure to have a perfect figure, with so much of images of flawlessness and shapely females all over the place. This is not only true of women but become increasi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

gly important for men too, that is, to have a good physique. . Changes in jobs, competition, traumatic events all can bring about bulimia. . Parental pressure on thei

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

children to maintain a shapely or thin figure can be another reason for children to become bulimic.

Some signs that an individual could be bulimic:

Eating in secret, binge

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

eating, fluctuations in weight usually ranging between ten and fifteen pounds, constant vomiting leading to swollen and soreness in the salivary glands, using diet pills or

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

axatives, rigorous exercising, depression and mood swings, muscle weakness and fatigue, teeth getting decayed because of constantly being exposed to gastric juices which are

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

cidic, heart beat is irregular, sore throat, suicidal tendencies, fasting, visiting the bathroom after every meal, always seeking other people's approval, broken blood vessel

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

especially in the eyes.

There are essentially three types of Bulimia Nervosa. They are Simple Bulimia Nervosa, Anorexic Bulimia Nervosa and multi-impulsive Bulimia Nervosa

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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