E-Articles - Health and Fitness

Bulimia is generally characterized by periods of bingeing and purging. Bingeing may be defined as an episode wherein an individual consumes a large amount of foo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d in a short period of time, but bingeing can take on a different definition for everyone. Some may consider 1,000 to 10,000 calories a binge while for others, a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

single chocolate bar can be considered a binge.

After every binge episode, the affected individual feels so terribly guilty and disgusted over his or her action

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s that he or she needs to eliminate all the calories that were taken in during the bingeing episode. Hence, the purging starts.

Bulimia disrupts the body's norm

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

l functions. As such it can lead to several health complications which can be serious and even life threatening. The complications which are experienced by an i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ndividual are highly dependent on the type of purging used.

Among the most common complications are those of cardiovascular, digestive and dental origins. Bulim

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ia is also known to affect the potassium levels in the body fluids and most commonly lead to medication and drug abuse.

. Bulimia leads to a number of cardiovas

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ular problems. Imbalances in the electrolyte levels in the body or the misuse and abuse of a drug called ipecac syrup can cause heart abnormalities. These are k

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

nown to cause irregular heartbeats, rapid heart rate, chest pains, breathing problems and cardiac arrest. It may also instigate low blood pressure and fainting o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

r dizzy spells.

A word of advice: Ipecac syrup is very dangerous and should only be used to induce vomiting in cases of accidental poisoning. Using it for other

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

purposes such as for purging is considered a grave misuse of the drug and may lead to various problems.

. Forced and frequent vomiting may harm your digestive s

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ystem. Repeated vomiting instigates the swelling and appearance of sores in the mouth, throat and salivary glands. It may likewise rupture the linings of the st

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

omach and the esophagus, which may lead to serious bleeding. Continued use of laxatives may likewise lead to the dependence on the drug and disrupt the normal bo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

wel function causing constipation and diarrhea. Peptic ulcers, pancreatitis, stomach pain and bloating can also result from this disorder.

. The acidic nature

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

f the gastric contents in the vomit may destroy the teeth enamel leading to an increase in dental cavities. Teeth may also become chipped, ragged and more sensit

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ive to hot or cold food.

. The electrolyte balance in the body is greatly affected by constant purging. When the potassium level in the body becomes critically

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

low, weakness and irregular heart rhythms may be experienced. At worst, death due to cardiac arrest may result from grave electrolyte imbalance.

. Using over-

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

he-counter drugs such as laxatives, diuretics, appetite suppressants and ipecac syrup may make a person dependent on these medications and create a drug abuse iss

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ue. This drug dependency may take a step further and instigate alcohol and substance abuse.

Aside from these, bulimia may also trigger the onset of amenorrhea (

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

loss of menstruation) and irregular menstruation, depression or mood swings, hair loss, kidney and liver damage, swelling of the hands and feet (edema) and anemia

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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