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Unhealthy eating patterns lead to an eating disorder. This is very common among teenage girls who are obsessed about becoming thin, and start harming their body by not eating. Poor nutrition harms their body

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

organs. This is a very serious problem as it affects them mentally as well, and leads to depression and anxiety. An eating disorder can be overeating as well.

When a person finds refuge in food to cover th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

eir mental disturbance, then they are suffering from an eating disorder.

The three most common types of eating disorder are:

Anorexia
Bulimia
Compulsive eating

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

orexia:

This is a psychological disorder, mostly seen in teenage girls, as a result of low self esteem or emotional or physical abuse. Obsession to become thin is the main reason for these people t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

o start over dieting. The more they lose weight, the more they have the drive to push further. They stop worrying about their body, and they become only interested in losing weight. They starve so as to take

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

control over the body. They start neglecting their health, which can sometimes even lead to death. This disorder is also a type of addiction.

They develop psychological fear of food and

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

fatness, which leads them to the extent of vomiting out anything and everything that they eat. Some people also start using laxatives to reduce weight. No matter how thin they grow, they are never satisfied.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

Bulimia:

This is also similar to anorexia, where the person becomes obsessed with growing thin. Here the person may binge on food, then throw up ever

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ything she/he just ate. They may first eat a large amount of food, and even indulge in rich food in a short period of time, then later force themselves to vomit. They may also start exercising excessively, u

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

se laxatives, or fast to make up for the food they had, as they start to feel guilty about having eaten food. Bulimia is most common in adolescent and young adult women.

Unlike anorexia where the person sto

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ps eating, bulimic people do eat food, but they either force themselves to vomit or use laxatives.

Health problems related to Anorexia/Bulimia

They are:

Poor circulation of blood
Irregular

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

menstrual cycle

Brittle bones

Infertility

Fainting and dizziness

Dehydration leading to kidney damage

Slowed heartbeat

Low blood pressure

Reduced bo

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

dy temperature

Hair loss

Compulsive eating:

When a person starts binging, leading to a feeling of guilt and shame, she/he is said to be a compulsive eater. This is not li

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ke bulimia where the person involves purging. This leads to weight gain and depression. Here the person has an uncontrolled urge to eat all the time. 40 percent of people who are obese are binge eaters.

How

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

would you know if you are a compulsive eater?

These are common signs of a compulsive eater:

Eating uncontrollably
Depression
Dieting frequently
Preoccupied about their wei

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ght

Vigorous exercise or vomiting to lose weight

Health problems like heartburn, dental problems, fatigue, weight gain, insomnia and high BP.

Treatments:

Recovery

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

from these disorders is possible. The person must undergo certain lifestyle changes with the help of the people around him/her. There are different kinds of psychological therapy available to treat these pr

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

oblems. For a person suffering from anorexia, hospitalization may be necessary in extreme cases; when due to severe weight loss different parts of the body get affected. Intravenous feeding may be required,

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

and the focus would be on gaining weight. Family support and assistance is very important. The person is given nutritional education for a healthy alternative to weight management. A lot of counseling is giv

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

en, and therapy to boost up one's self esteem. Everyone has the right to love his own body.

So with the help of medical, psychological and nutritional assistance, people with eating disorders can be healed.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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