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In this second article on Bulimia Nervosa we're going to go over the effects the disease can have on the body and how to treat it.

Bulimia nervosa can have dev

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

astating effects on a person's body if the disease goes unchecked for a long period of time.

The most serious of these is electrolyte imbalances which are caus

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d by the constant bingeing and purging. These imbalances can lead to irregular heartbeat. If the problem goes on long enough this can lead to heart failure an

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

death. The actual cause of the electrolyte imbalance is because of loss of potassium and sodium from the body and dehydration because of the constant purging.

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Another serious problem is caused by the frequent vomiting. That problem is inflammation of the esophagus, which at best can cause difficulty in breathing an

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

at worst possible rupture.

Another problem people with Bulimia Nervosa suffer from, while maybe not as serious as the ones mentioned already, is tooth decay f

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

om the frequent vomiting. This decay can eventually lead to tooth loss. While that may not sound all that terrible, it has been shown in studies that people w

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ho have their own teeth live longer than people who wear dentures. So this is something to be concerned about.

Because of the constant laxative use a person s

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ffering from this disease will eventually have infrequent and irregular bowel movements and most likely end up suffering from chronic constipation. This can ca

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

se more serious problems down the road if this condition persists for any length of time.

And finally there is the possibility of gastric rupture because of th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

binge eating. This particular problem is very rare, even in the worst cases of Bulimia Nervosa, but nevertheless the possibility still exists, especially if t

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

he disease goes untreated for any length of time.

And now, some facts and statistics about the disease itself.

Bulimia Nervosa affects between 1 and 2% of all

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

teenage or young women. The reason for this is mostly psychological because girls at this age are very self conscious about their looks and when they develop t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

is irrational fear that they are too heavy, resulting in a poor social life and low esteem, they are likely to fall pray to this disease because of those fears.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

About 80% of all patients suffering from this disease are female. Again, this all goes back to society, especially TV commercials, convincing young women tha

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

they have to be skinny as rails and look like fashion models if they are going to be accepted.

The truth is, the majority of people who suffer from this disea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e will appear to be of average body weight and will not at all appear to be fat.

Oddly, many people with Bulimia Nervosa do recognize that they have a problem.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

They know that the habits they have picked up of bingeing and purging are not normal. Yet they are unable to stop themselves, much like a person who knows sm

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

king is harmful but can't quit.

Psychiatrists have determined that the onset of the disease is usually associated with depression, which is usually brought on

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

y the person feeling inadequate as far as his or her appearance.

In our last article on this subject we'll go over how a person with Bulimia Nervosa is treated

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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