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E-Articles - What Causes Carpal Tunnel Syndrome?
With the birth of technology and the rise in popularity of the cellular phones as a mode of communicating with people, we have become addicted with using the short messaging system. Text messaging via cellph
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
one is also another way of communicating these days.
Because of these new avenues of communication, people make use of keypads all the time. And though this is an instant and fast way, not to mention cheap
Because of these new avenues of communication, people make use of keypads all the time. And though this is an instant and fast way, not to mention cheap
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
way, to stay in touch with people, it also has its disadvantages. One of them is putting strain in the hands, particularly in the fingers.
When you type, you are exerting much effort with your fingertips. Y
When you type, you are exerting much effort with your fingertips. Y
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ou are pressing letters in order to compose messages. And though it is not exactly dangerous, it can be exhausting for the fingers if done all the time. One of the problems that may occur due to the repetiti
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ve typing is carpal tunnel syndrome.
Carpal tunnel syndrome is a progressive condition that is characterized by pain in the wrist, fingers and sometimes even the whole arm. It is one of the most common form
Carpal tunnel syndrome is a progressive condition that is characterized by pain in the wrist, fingers and sometimes even the whole arm. It is one of the most common form
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
s of what scientists and doctors call the entrapment neuropathies, which involves the compression or traumatization of the peripheral nerves.
Carpal tunnel, to those who are not familiar with the term, is t
Carpal tunnel, to those who are not familiar with the term, is t
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
hat part of the wrist at the base of the palm. It is a narrow passageway composed of ligaments and bones that houses and protects the tendons in the hands and the nerve fibers.
This is where we can find the
This is where we can find the
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
median nerve, which runs from the wrist to the forearms. This is the nerve cell that controls the sensations in the area of the palm, including the fingers. This also acts as the messaging headquarters of i
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
mpulses for the fingers. This is why when the median nerve is compressed or affected in some way, the fingers may find it hard to move.
Pain occurs when tendons in the carpal tunnel swell, making the alread
Pain occurs when tendons in the carpal tunnel swell, making the alread
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
y cramped space in the tunnel all the tighter. This compresses the median nerve, resulting in the numbness of the area and weakness of the surrounding muscles.
There is currently no one specific reason for
There is currently no one specific reason for
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
he occurrence of carpal tunnel syndrome. Often, it is the combination of a lot of factors that affect the median nerve and the tendons. Experts suspect that it is mainly due to congenital predisposition rath
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
er than anything that is developed from the environment. There are just some people who have smaller carpal tunnels than other people, thus predisposing them to the problem.
Still, there are also some facto
Still, there are also some facto
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
rs in the environment that may contribute to the exacerbation of the problem. People who have suffered some trauma or injury at the wrist may cause swelling which in turn may affect the median nerve. The sam
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
e goes with sprains and fractures. Over-activity of the pituitary glands, hypothyroidism and rheumatoid arthritis may also be factors that can cause carpal tunnel syndrome. Work stress especially with the re
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
peated use vibrating hand tools and mechanical problems in the joints are also factors.
Women who retain fluids in their bodies during pregnancy or during menses also suffer from the condition. In some case
Women who retain fluids in their bodies during pregnancy or during menses also suffer from the condition. In some case
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
s, doctors cannot even pinpoint an exact cause for the problem.
Although it is widely believed that carpal tunnel syndrome is the effect of repeated and forceful movements of the hands such as when you are
Although it is widely believed that carpal tunnel syndrome is the effect of repeated and forceful movements of the hands such as when you are
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
typing, there is still no clinical data that will conclusively confirm this. Still, repeated motions that are often performed may result to disorders such as bursitis and tendonitis.
Carpal tunnel syndrome
Carpal tunnel syndrome
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
should of course be differentiated with writer's cramp, which is a completely different problem. Writer's cramp is a condition where there is lack of coordination in the fine motor skills. This often results
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
to an ache and painful pressure in the fingers, wrist and forearm.
Unfortunately, women are three times more likely than men to develop carpal tunnel. This is perhaps because women have traditionally small
Unfortunately, women are three times more likely than men to develop carpal tunnel. This is perhaps because women have traditionally small
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
er carpal tunnels. The dominant hand or the one being used more is often the first one to be affected. Often, when both hands are already affected, the dominant hands will be much more painful than the other
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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