E-Articles - Health and Fitness

You most likely have a six-pack right now. Whether or not you can see it depends on your body fat level. Most people star

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t to notice their six-pack around 10% body fat, if you do not know your body fat level you can use the instructions below

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to calculate it.

Body Fat Formula for Men

Factor 1 (Total body weight x 1.082) + 94.42

Factor 2 W

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

aist measurement x 4.15

Lean Body Mass Factor 1 - Factor 2

Body Fat Weight Total bodyweight - Lean Bo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

dy Mass

Body Fat Percentage (Body Fat Weight x 100) / total bodyweight

In order to see your six-pack you mu

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

st reduce your body fat level, one way to do this, is cardiovascular exercise, or cardio. Cardiovascular exercise refers

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

to any exercise performed at moderate levels of intensity, for an extended period of time that maintains an increased hea

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t rate. At first the body uses glycogen to produce glucose (sugar), to give you the energy to perform the exercise. But,

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

after the supply of glucose is gone, the body is forced to use fat for energy; this is the effect we are trying to achiev

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e with cardio.

There are 2 factors you should consider when planning a cardio program, duration and frequency.

Duration

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Beginner: It is recommended that you exercise for 10-15 minutes and add more time as you gain endurance.

Intermediate/

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Advanced: It is recommended that you exercise for 30-60 minutes and vary the intensity based on your level of fitness.

F

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

requency: Cardio should generally be performed 3-5 times a week, with at least 24 but no more than 48 hours, between work

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

outs.

How to perform a cardio workout:

1) Before you begin a workout, it is vital that you warm-up. You should per

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

form the cardio exercise of your choice, (jogging, biking) for 5-10 minutes at low intensity to warm your muscles up, (he

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lp blood circulate through them). After you are warmed up, you should stretch the main muscles you will be using to perfo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

rm the exercise, or 5-10 minutes.

2) Perform your cardiovascular exercise of you choice, for the duration that you

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

have chosen.

3) Don’t forget to warm down! Perform the cardio exercise of your choice for 2-5 minutes at low intens

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ity to cool down. Then stretch the primary muscles used in your exercise for 5-10 minutes. This last step is crucial, and

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

greatly decreases the chance of injury, and helps improve your performance and results.

Find more articles like this at

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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