E-Articles - Health and Fitness

When I go into my garden with a spade, and dig a bed, I feel such an exhilaration and health that I discover that I have been defrauding myself all this time in letting others do for me what I should have done

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

with my own hands.
- Ralph Waldo Emerson

Spring is in the air, the trees are budding, the flowers are blooming and your waistline is sprouting. Oops! No need to panic, whatever the season. Pi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ck up your rake and head out to your garden. Prune your rosebush, whittle your waistline and simply breathe…fresh air fitness. Ahhh! Work your body, work your garden, increase your energy levels and take the tim

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

to stop and smell the roses.

Dig In the DIRT
• Do something!
Use these ideas or create your own workout… just do something! Don’t get caught up in the exercise du jour. The perfect exer

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

cise is the one that you enjoy and will do consistently.
• Increments work
The Surgeon General requires a minimum of 30 minutes of moderate activity each day. Make small deposits of exercise t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

owards your daily goal. Take a 5, 10-minute walk, stretch 5 minutes, strength train for 5 minutes. It all counts!
• Resourceful Ideas
No expense required. No need for a fancy gym or the latest fi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ness gadget to get results. And the great outdoors is a natural resource of negative ions, which give you extra energy!
• Tailor it
Personalize the movements to your needs. Listen to your body, spe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nding more or less time on movements as you see fit. Be your own personal trainer!

A Garden Workout – 10 Simple Exercises

Exercise Equipment: rake, broom or tree
1. Lilac Leg Swings (S

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ecure rake into the grass, handle side down, fan side up) Stand side-by-side with rake, holding rake with one hand – find your balance – swing right leg front and back (working thighs and buttocks) 10x
2. Bi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d of Paradise Back Stretch – Face rake, feet hip width apart, hold rake just below metal fan, arms extended long. Let your head hang through your arms. Breathe 3 breaths - Keep your abs tight. Feel a stretch along

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

your arms, torso and low back.
3. Wax flower Waist Whittler – Standing feet hip width apart - Place the rake horizontally across your upper back, gripping wide along the rake’s handles. Feel your chest open

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

up and your posture improve. Hold 6 breaths. Inhale and exhale as you twist right. Center. Inhale and exhale as you twist left. 5x each direction
4. Bellflower Bend – Standing feet hip width apart – hands

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

gripping wide along rake’s handle – arms extended overhead. Inhale and exhale as you bend to your right – inhale and exhale as you come center – inhale and exhale as you bend left – inhale and exhale as you come cen

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ter. 5x each direction
Exercise Equipment: 2 bricks
5. Baby’s Breath Bicep Curls – Standing, feet hip width apart, bricks in each hand, arms at sides. Rotate palms up and lift hands to shoulders

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

by bending your elbow and keeping it in to your waist. Slowly lower. 10x
6. Tulip Triceps Kick Backs – Standing, feet hip width apart, bricks in each hand, and arms at sides. Palms to the back- raise your st

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

aight arms behind you – hold 3 counts and slowly release. 10x
7. Sunflower Shoulder Raises – Standing, feet hip width apart, bricks in each hand, and arms at sides. Slowly raise your arms straight out to the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

side to shoulder level and slowly lower. 10x
8. Amaryllis Abs – As you are bending over planting, tightly squeeze abs – hold 5 seconds and release. 10x (or more)
9. Thistle Thigh Toner – kneeling (on padd

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ed surface), body upright, hands on waist. Slowly (keeping your upper body in a straight line) Lean back 1 inch – inhale – exhale to tighten abs & bring whole body forward. 5x (skip this exercise if you have knee

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

njuries or a bad back.)
10. Cat Stretch Stattice – on all fours – inhale, drop your head and tailbone to round your back and exhale your tailbone up – arching your back and head up to smell the flowers. 5x

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Heed Mr. Emerson’s wise words: “Go into your garden, pick up your spade,” dig in the dirt and find “exhilaration and good health,” simply. What do you have to lose? An inch or two…and your monthly gardening bill

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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