E-Articles - Health and Fitness

This is the second part of our article on sciatica. Please can I re-iterate that if you do get the symptoms of sciatica you

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

MUST get checked out by a medical professional before embarking on any kind of exercise. The symptoms of sciatica are as

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

follows:

Pain in the lower back that radiates down the back of the leg. A feeling of numbness below the knee; there may

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e tingling or numbness in the toes. Pain down the back of the leg accompanied with a feeling of unsteadiness or bowel/bla

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

dder incontinence. Sciatic pain can vary from infrequent and just annoying to severe and debilitating.

Okay, that’s the

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

owdown. So we assume that you’ve been cleared to exercise. What can you do to relieve your symptoms? Well, here are some id

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

as:

Try heat and / or ice packs (remember ice must NOT come into direct contact with skin). This can be applied fo

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

r around 15 minutes at a time three to four times a day.

Don’t lie around in bed unless ordered to. Inactivity ca

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

make sciatica worse. Get up and get moving, Soldier!

Walking is marvellous exercise. Stride out there!

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

Try some Aqua Aerobic classes. Most public pools hold them, or you could join a gym that has a pool. Even walking in the wa

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

er is good exercise. Borrow a small child and chase it across the pool pretending to be a crocodile. If you catch said chil

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

d, eat it!! Kids never, never get tired of this game…you’ll be exhausted and have burned zillions of calories by the time t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ey’ve had enough…

Go to Pilates classes (well, I was bound to put that one in somewhere!). Pilates focuses on str

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ngthening your core muscles in your stomach and back…I’ve known people in my own classes who no longer get sciatic pain. Ex

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ercises lying on your back and stomach are the most effective and least likely to set the pain off. You have to go to class

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

regularly, though and also exercise at home…there is no quick fix!

Stretching exercises can also be very effectiv

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

in relieving the pain. It is well worth paying for a few sessions with a properly qualified Personal Trainer or a Pilates

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Instructor with a one-to-one qualification. In short, sciatica can be miserably painful, but the good news is t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

at permanent nerve damage is rare, and in most cases there are ways to help yourself. So remember my Three Esses (!)

STRID

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

out and have a brisk walk every day. So it’s raining? You ain ’t gonna melt!

STRETCH those muscles…

STRENGTHEN that core

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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