E-Articles - Health and Fitness

Bodybuilding and exercising requires good health, and most important of all, ENERGY! Most people don't realize that a great source of energy is vitamins. So, what vitamins fa

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cilitate energy production?

Vitamin B5 (pantothenic acid)

A water soluble vitamin that is needed in the making of fatty acids and glucose (the simplest form of carbo

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

hydrate that the body can burn), which forms the main sources of fuel for the body. (Do you know that the brain only burns glucose? B5 may help improve co-ordination!) When f

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ound in its CoA form, vitamin B5 plays a vital role in helping release energy from sugars, starches, and fats. Most of this energy release occurs in the energy production fac

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ories found in every cell called the mitochondria. Increased levels of vitamin B5 in the blood of marathon runners, for example, has led to interest in this vitamin as a pote

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ntial aid in physical training, where sustained energy release from the mitochondria is critical.

It is also essential for the making of steroid hormones and neuro-transmitt

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ers in the brain (body co-ordination).

Vitamin B5 is widely found in foods and the RDA is only 6mg per day, but once again it will not satisfy the needs of an athlete. Panto

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

thenic Acid supplementation of 2.0g per day has shown to reduce lactate build-up by 17% and oxygen consumption by 8%. In addition, B5 is easily destroyed in cooking and moder

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

food processing. See our article on acne and vitamin B5 deficiency.

Zinc

Think zinc for growth. That's right, the mineral zinc is involved in virtually all phases o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

f growth. Even more critical for bodybuilders, studies have shown that high intensity exercise stimulates excessive zinc loss. Further, diets of some athletes have been found

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

to be low in zinc. This potential double edged sword, excess loss coupled with possible low intakes, moves zinc into our number three position. If you're not mindful of your

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

zinc intake, your growth may be stymied.

Biotin

Firstly, as part of the B-complex vitamins, it forms part of two important enzymes, pyruvate carboxylase and acetyl-

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

oenzyme A carboxylase. These two are essential for gluconeogenesis (formation of new glucose) and fatty acid synthesis, which forms two of the major fuel sources for the body

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

. Secondly another coenzyme called 3-methylcrotonyl coenzyme A carboxylase is essential for the breakdown of branched-chain amino acids, which means without it the body canno

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

t break down these amino acids to use them again as building blocks for muscle. Deficiency of Biotin will speed up the balding process, and leave you skinny and weak. Active

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

people should take 300 to 5000mcg daily, even though the RDA specifies only 30-100mcg. The best food sources for Biotin are liver, sardines, egg yolk, and soy flour. Raw egg

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hites as used by some bodybuilders contain Avidin, which binds biotin and make it useless for the body.

Vitamin A (Retinol)

Named after the retina of the eye, retino

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

l is an oil soluble vitamin that is essential for vision (especially night vision), the skin and mucous membranes, cell growth, reproduction, and normal immunity. Sources of

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

this vitamin are liver and fish liver oils. Beta-carotene, the precursor of Vitamin A, can be found in carrots and dark green leafy vegetables. One large carrot for example c

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ontains 18 000 IU of beta-carotene, which is more than three times the RDA of 1000mcg RE (retinol equivalents). It takes 6 mcg of beta-carotene to yield 1 mcg RE of vitamin A

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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You probably heard the same old BS from your upline that you must plug into the system and order their weekly motivational CDs if you want to be successful. And if you stop wasting your hard earned money on these useless audios, you will fail miserably with the company. Well, here is the REAL dark secret why your so called trusted upline pushes these weekly motivational tapes to you.

Have you seen all those big full page ads for hedge funds in the Wall Street Journal, the Financial Times, Investors Business Daily? You haven’t. Maybe they are being drowned out by the regular mutual funds who continually tell you how great they are...

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