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E-Articles - Aging and Aching Muscles
As we get older we begin to complain more about the pains we get in muscles and joints. When I was younge
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
r I couldn't understand why people that were only 10 or 15 years older than I was complained about the af
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
ter effects of any sort of exercise (but I’m beginning to see their point of view!).
As we stiffen with
As we stiffen with
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ge, even commonplace activities such as bending down to pick up the morning newspaper make people wince i
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
n the anticipation of the aches.
Some aches and pains that people claim are so fierce that it feels like
Some aches and pains that people claim are so fierce that it feels like
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
the aches begin deep in their bones. However, research suggests that the cause is not the bones but in f
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
ct the connective tissues that move the joints and in the muscles.
The amount of stiffness that people e
The amount of stiffness that people e
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
xperience can be determined by the amount of flexibility a person has in a joint. For example some people
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
are able to bend over and touch their toes with legs straight, whereas others are not.
Flexibility and
Flexibility and
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
ase of movement depends on several factors. In joints such as at the elbow and knee the bone structure it
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
self determines the range of movement. Other joints such as the hip and ankle, soft tissue (muscle and co
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
nnective tissue) limit the range.
The inflexibility of joints and muscles is similar to how a rarely use
The inflexibility of joints and muscles is similar to how a rarely use
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
gate opens and closes with a rusty hinge. Hence, people stand to lose some potential in motion if they d
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
o not regularly move their muscles and joints. This explains why when people try to move a joint after a
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
long period of inactivity they feel discomfort and pain, which then discourages further use.
Infrequent
Infrequent
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
se of muscles and joints causes the shortening of muscles that can lead to cramps and spasms that can be
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
extremely uncomfortable. Infrequent use is not the only cause of sore muscles though. Too much exercise,
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
aging, and immobility can also affect muscle soreness.
Each individual is different and so it is importa
Each individual is different and so it is importa
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
t to know your own limitations in order to avoid sore muscles. What matters most is how people stay fit b
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
y doing regular exercise at a normal range, rather than exercising once every so often at a rigid routine
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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