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Aqua exercises, or water exercises, are increasing in popularity across the general public. What physical therapists and sports clinicians have known for years

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

is now becoming public knowledge. Sports and fitness clubs offer classes for water aerobics, water exercise and trainers who incorporate water work for rehabili

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

tation and strength training.

Water exercises are a healthy and physician approved method of regaining strength during and after an injury. They have also been

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

found to be beneficial for pregnant women and recent moms, people with painful joints or people who are learning how to exercise.

Before starting any exercise

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

program you should always consult with your physician. They can accurately advise you about the risks and benefits in your particular situation.

Exercises can

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

be done with little to no specialized equipment such as flippers, flotation belts, weights or noodles. Initially the workout begins in the shallow end of the po

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ol and progresses to a place where the person is in water reaching their neck.

Aqua aerobics incorporates many of the aerobic exercises that are done on land, w

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

hile aqua exercises are resistance and strength training aimed at improving strength and mobility. In either case the exercises are actually more strenuous than

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

those that are land based and, at the same time, offer more support to soft tissue and joints.

Just because working in the water is easier on your joints and m

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

uscles doesn’t mean the workout is easier than land based exercise. Joints and muscles are under resistance during the whole exercise as opposed to land work wh

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

en muscles work only against gravity. Muscles are forced to work harder, burn more fat and tone faster. Because of the pressure of the water on your legs more

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

blood is forced to the upper part of your body making the heart work harder and burn more calories.

Benefits to water exercises include:
• High calorie bur

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n during a workout
• Support only 50% of your body making the workout easier on soft tissue and joints
• Good alternative exercising for people with jo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

int disease, obesity and recovering athletes
• Water relieves stress and tension
• Water’s buoyancy decreases the risk of exercise related injuries

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

• Great year round activity using an indoor pool

If you don’t have classes in your area you can incorporate water exercises by simply walking, jogging or runn

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing in the water. Start at the shallow end of the pool and walk through the water from one side of the pool to the other. Start by doing this for 5-7 minutes e

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ach session working up to 20 minutes. Once you’ve reached 20 minutes start moving into deeper and deeper water until you are walking through water that is chest

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

high. You can move on to jogging or running in the water too.

Remember you were not born in the water! Although these exercises increase your comfort in the w

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ater and improve your swimming skills you continue to sweat. It is possible to become dehydrated while swimming. Remember to drink both before your workout and

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

afterwards.

With a bit of practice and some time your skills at aqua exercises will improve your land based performances and decrease your potential for injury.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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