E-Articles - Health and Fitness

For most of us, the summer sunshine is a welcome relief from the doom and gloom of the w

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

inter months. However, for around one in four of the UK population, the advent of summer

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is a time of misery and discomfort.

Seasonal allergic conjunctivitis, also known as ha

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y fever eyes, is very common in the UK. As the name suggests, it is an allergic reaction

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

to tree and grass pollen that builds up in our atmosphere as the weather gets warmer. T

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hose who suffer from the condition complain of itchy, red, watery eyes whilst in severe

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

cases the eyes become so sticky that it hurts to open them.

The problem can be exacerba

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ted in contact lens wearers largely because dust and pollen can get trapped beneath the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

surface of the lenses.

Although it is certainly advisable to seek medical advice and he

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lp if you are a lens wearer suffering from seasonal allergic conjunctivitis, the followi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ng tips might also help:

1. Ideally you should try not to wear your contacts if it is v

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ery dry and dusty outside. If you do still want to wear your lenses in these conditions,

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

consider wearing sunglasses as well. This will help to provide a barrier between the du

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

st and pollen and your eyes and lenses.

2. Don’t wear your contact lenses while mowing

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the lawn.

3. You could try asking your optometrist about lubricating eye drops which mi

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ght help moisten your eyes and relieve your discomfort.

4. If the pollen count is parti

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

cularly high, think about wearing glasses instead of your contacts.

5. Be careful not t

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

o get suntan lotion on your lenses as this will make your eyes sting- ideally you should

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

not even sunbathe in your contacts.

6. If you are out and get dust in your eyes, avoid

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the temptation to remove your lenses and either rinse them under a tap or in your mouth

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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