E-Articles - Health and Fitness

You just woke up after attending a wild party the night before. The hangover is gone and so is the bad taste in your mouth after all

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the food and drinks you’ve consumed. Now you’re ready to face the world again as you get ready for the office.

But as you stare in t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

he mirror, you’re confronted by a stranger! Somehow, there’s something different about you. Then from out of the blue, it suddenly hi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s you! You look terrible and it’s because of those dark circles under your eyes!

Dark circles below the eyes are no big deal. Everyo

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ne gets them from time to time. If you’re a party animal, chances are you’d get them more often since the condition is common in peop

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

le who don’t have enough sleep, are constantly under stress or sleep in a position that allows fluid to collect in the lower eyelids.

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

This causes the eyelids to swell creating the appearance of shadows below the eyes.

In most cases, the problem is simply cosmetic an

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

d not a serious health hazard. You can blame it on your parents for the condition may be inherited. However, as trivial as their caus

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

es are, dark circles shouldn’t be ignored for in some instances they may mean something else. If the problem persists or worsens, it’

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

wise to see a doctor.

“Dark circles under the eyes can be the result of allergies to airborne substances, such as pollen, dust, and

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

pet dander, because people rub their itchy eyes. People with hay fever may notice them at the height of the season,” according to Ca

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

thy Wong of the American College of Nutrition.

“Blood vessels under the eyes can become dilated and engorged, which can contribute t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

dark circles. Excess dietary salt and smoking are common causes. Conditions that cause fluid retention (e.g. heart, thyroid, kidney,

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

liver diseases) or medications that cause blood vessel dilation may be a factor. Your doctor should be aware of any symptoms you're

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

experiencing,” she added.

To get rid of dark circles, here are some home remedies courtesy of Wong:

● Drink enough water.

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

● Wear sunscreen with a minimum of SPF 30 under the eyes to prevent skin weakening caused by sun damage.
● Get ple

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

nty of rest.
● Apply plain cool teabags over closed eyes. Don’t use herbal teabags because most aren't as effective.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

● Apply cool cucumber slices over closed eyes for 15 minutes.
● Don’t consume too much dietary salt.
●

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Apply vitamin K cream. Although studies haven't looked at the use of topical vitamin K for dark circles under the eyes, preliminary s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tudies have found that vitamin K may help with bruising.
● Take enough vitamin C to help strengthen blood vessel walls.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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