E-Articles - Health and Fitness

You’ve probably heard it all before – from your friend, lover, mother-in-law or even your next-door neighbor. Staying up late at night and stress can

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

cause dark circles under the eyes. However, the truth may surprise you.

While fatigue and burning the midnight candle can contribute to the condition

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

, dark circles under the eyes are often the result of nasal congestion, according to Mayo Clinic dermatologist Dr. Lawrence Gibson.

“You may be surpr

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ised to learn that fatigue usually isn't the cause of dark circles. Instead, the most common cause is nasal congestion. When your nose is congested, v

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

eins that usually drain from your eyes into your nose become widened (dilated) and darker,” Gibson explained.

Eyelid swelling during sleep is another

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

common cause. When you lie down, fluid collects in your lower eyelids because of gravity. As the eyelids swell, this may create the appearance of sha

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

dows or dark circles below your eyes.

Other possible causes are chronic skin conditions such as atopic eczema (also called atopic dermatitis), a dise

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ase characterized by red, flaky, and itchy skin, and fluid retention due to excessive salt intake, too much smoking, and heart, kidney or liver diseas

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e. The condition may also be a sign of dehydration or iron deficiency anemia.

But don’t panic! In most cases, the condition is temporary and not a se

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rious medical problem. It tends to run in families so if one of your parents have it, chances are so will you. As blood passes through tiny capillarie

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s close to the surface of the eyes, it becomes more noticeable in fair skinned people, contributing to dark circles. The problem becomes worse with ag

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ing since the skin under the eyes becomes thinner, making the blood vessels or dark circles more visible. If you love the outdoors and spend a lot of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

time under the sun, you may also develop dark circles below the eyes because the harmful rays of the sun can weaken the skin.

To get rid of those dar

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

k circles, here are some tips from Dr. Mark Van Wormer, a board certified diplomat of the American Board of Anti - Aging Medicine:

“Place cotton pads

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

soaked in eye soothing fluid in the refrigerator. On the morning you wake up with puffy eyes or in the evening when you must go out after a long hard

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

day's work but those dark circles are jumping out at you in the mirror, do the following:

• Start by removing all eye makeup.
• Lie down wi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

th feet up.
• Place the cool soaked pads over eyes.
• Rest 10 minutes while listening to soft, soothing music.

“Ten minutes later, your puf

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

finess will be gone and you will look rested,” he said.

Some people swear by Eyevive, an eye cream for men and women that strengthens tiny vessels ar

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ound the eyes to reduce the formation of dark circles, fine lines, wrinkles, and puffiness. This breakthrough formula contains special ingredients enh

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

anced with green tea extract, aloe and Pro-Vitamin B5 to give you a fresher and more vibrant look. For more information, visit http://www.eyevive.com.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Satellite radio is a service that is available through subscription that will give you access to music, talk shows, sports games, and many more. This service is commercial free and is only available with a monthly fee to a provider.

People who complain that they feel old usually lack the energy or motivation to do something they've been invited or need to do. In reality, the culprit is an out-of-shape body, not age. Exercise can help you have more energy, feel younger, and look your best too.

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