E-Articles - Health and Fitness

Tobacco Amblyopia results from the excessive use of tobacco, either by smoking or chewing. And also occasionally from the absorption of dust in t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

obacco factories. Smokers of shag and strong tobacco mixtures or cigars suffer most. Cigarette and beedi smokers are affected often. In many ca

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

es there is also over- indulgence in alcohol. The patients are usually 35 to 50 years of age, may have smoked excessively for years with impunity

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the attack coinciding with some intercurrent cause -debility or digestive disturbance.

Various substances have been regarded as the toxic agent

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

but a potent factor may be poisoning with the cyanide in tobacco smoke associated with a deficiency of vitamin B12.

The patient complains of in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

creased fogginess of vision, usually least marked in the evening and in a dull light. Central vision is greatly diminished, so that reading and n

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ar work become difficult; although the condition is bilateral, one eye is usually more affected. Patient finds very difficult in bright sunlight.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

On examination, one can find the peculiar bad smell of tobacco, trembling of hands. Except for the diminution ofvision, in all other respects ey

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

would be almost normal. After dilating pupil and examining the retina in detail also, one cannot find any significant changes. The only test whi

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ch helps to diagnose the disease correctly is the visual fieldexamination. The purpose of doing this examination is to know whether all the parts

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

of the retina are equally sensitive to light, and also to find out the non - seeing areas.

Pathologically the condition is due to degeneration

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

of the ganglion cells of the retina, particularly of the central areas where the cells show vacuolation and Nissl degeneration. Since the central

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

area is affected, patient feels the fogginess of vision. Initially it may not pose much problem for the patient,but if it persists, the patien

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t may become almost blind, because he would not be able to see the central objects because of the central blindness.Therefore the disease has to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e diagnosed in the earlier stages, so that the proper treatment can be instituted and the blindness can be halted.

Treatment consists of abstent

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

on from or severely curtailing the use of tobacco and alcohol. If this is done the prognosisis eventually good although the visual improvement ma

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

not be evident for a period of some months. Improvements may be hastened by large doses of vitamin B preparations (B1 and particularly B12 ).I

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t is unfortunate that most of the time our patients fail to follow this strict regimen and slowly start smoking as well as drinking, with the res

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

lt that they would land up in their old misery.

Smokers should note that not only they are more prone for the respiratory diseases and heart p

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

oblems but also they may lose their precious eyesight partially or fully and should make serious efforts to give up smoking.

------ Dr.Mohan H.S

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Business Process Outsourcing (abbreviated as BPO) is a process of hiring additional stuff, who take care of some or all non-core but still important tasks. The main goal of Business Process Outsourcing is to give a company a chance to allocate more time, funds and work force into the most important and strategic activities, ensuring company success and development. This can be achieved by means of cutting down costs while outsourcing to other countries, than USA. This in turn helps to improve the productivity, because Business Process Outsourcing firms end to be rather flexible, quick, inexpensive and highly productive.

The cost of driving increases every year, and drivers are often willing to do whatever it takes to keep their costs down. That means going to traffic school if they commit a traffic violation. Traffic school saves drivers from having points added to their driving records, a necessary step to ensuring that already hefty insurance rates don’t skyrocket...

Three levels of chemical peels exist to correct different skin conditions. Some have dramatic effects eliminating wrinkles and removing precancerous skin lesions while others work on finer lines on the face and improve skin texture and radience.

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