E-Articles - Health and Fitness

The dual action motion of an elliptical trainer ensures that more calories can be burned than with a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

more traditional 'linear' exercise method such as running or cycling. The elliptical's handles - att

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ched to the pedals by a series of gears that enable it to utilise their momentum without being rigidl

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y constrained in terms of speed - allow for an upper as well as lower body workout. Since the upper

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ody is moving against resistance provided by the pushing and pulling of the handles, the result is a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ore effective calorific burn, a more efficient exercise motion that allows all the muscles to work in

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

unison, and much less impact than other forms of exercise.

The elliptical's handles can usually (ce

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

tainly always on the higher-end machines) be set to provide a level of resistance independent of the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

lliptical pedals. This makes for the ability to create a unique and benefiting training experience e

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

very time one steps onto the trainer.

Cross trainers, or elliptical trainers, are gaining momentum a

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

d popularity; this is for very good reason. Will it ever trump the treadmill? Who knows. Scientifi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sports research shows that elliptical trainers provide just as much or more of an effective cardiova

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

scular-based exercise than that of a treadmill and does so in a safer manner. Treadmills, by their v

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ry nature, force the user to pick up and put down their feet in rapid succession many thousands of ti

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

es during an exercise session, the fragile tissues, muscles and ligaments located in the lower body (

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

especially the knees and ankles) may be irreparably damaged.

The fluid motion of the elliptical mean

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

that the exerciser is not forced to pick up and hit back down with his feet and legs: there is no ja

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ring, shocking motion to transfer force into the legs. This gives an all-round safer and much more c

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

omfortable exercise. This also means that the energy used before to jar and resist jarring can now

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e used to work the muscles - which is probably what we all look for when exercising, not damaged legs

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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