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Treadmills can bring the outside into your own living room. Sounds ideal doesn't it. You can run 10 miles withour leaving your house.

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

But can treadmill running deliver the same benefits as training outdoors?

Treadmill running differs from road running in a number o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ways and this should be considered when training. The first obvious difference is the lack of wind resistance when running indoors.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Another difference is the surface. Although experts differ on this issue a smooth moving surface underneath your feet is not the same

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

as an uneven stationary road. Most runners agree that running on a treadmill feels different to road. This should be taken into consi

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

deration when training.

Is running on a treadmill better than the road? This comes down to preference. Many prefer being outdoors wh

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

reas others have environmental, climatic or personal safety concerns making treadmill running an ideal choice.

Firstly let's look at

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the psychological factors of running on a treadmill compared to the road. Unless you have a large room for your machine you will mos

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

likely to be facing a wall or window within a few meters. Research has shown that runners on treadmills take shorter paces that may

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

be due to the proximity of a barrier or fear of falling off. It does take time to learn how to run on a moving surface and even when

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

onfident many runners will tighten their lower backs, again possibly a psychological reaction to staying on the machine.

When compar

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ing physical technique, research has found that when the foot lands on the belt the foot, ankle and shin, become temporarily part of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

he belt and move backwards from the centre and mass of the body at the same speed. This means the shinbone of the leg landing is not

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

as upright as with normal running and has a greater range of motion.

Treadmill running can be useful for injured athletes, using a m

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

rror can be a good way to observe your technique (although it must be recognised that it is not the same as training on the road).

W

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hether using a treadmill or road you will need to vary your running program for two reasons. Firstly, if you continue doing the same

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

istance and the same speed you will get less and less benefit as your body adapts. Secondly, you can soon become de-motivated by the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

same thing week in, week out. Alternating between shorter faster runs and longer distances at a slower pace will help to condition yo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

r body and improve endurance, muscle strength and cardio-vascular function. It will also provide you with variety and a different cha

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

llenge for each session.

I usually recommend runners to use one or the other exclusively, because I see them as different activities

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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