E-Articles - Health and Fitness

There are many factors that contribute towards hair loss: hormonal changes, diet and nutritional deficiency, stress and poor

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

health. A major cause of severe hair loss is developing a thyroid problem. Both hypothyroidism and hyperthyroidism are respon

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

sible for causing severe early onset of hair loss in both men and women of all ages. Everyone seems to believe that these pro

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

lems will never happen to them and that a thyroid dysfunction is something that happens to old people. This is far from the t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ruth. We see male and female patients from all age groups. Ask your GP for a blood test immediately if you have a suspicion a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d consult one of our trichologists early on for advice. Early trichological treatment can prevent severe hair loss from this

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

condition and its associated prescription drugs. Hair growth has a three phase growth cycle: anagen, catagen and telogen dorm

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ant phase. When a person suffers from hypothyroidism or hypothyroidism, the general mechanism of the hair growth process shut

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

down and loses balance. Thyroid malfunctions can force hair follicles to remain in the dormant phase for a longer period of

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

time than normal. This leads to stalled hair growth and eventually to hair loss.

The thyroid is an endocrine gland, which is

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

located on both sides of the trachea. It secretes the thyroid hormone, known as thyroxin, which regulates the rate of the met

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

abolism. Any disruption in the mechanism can have great impact on overall metabolic activities. Once the metabolism is distur

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

bed, it has been found to cause a series of abnormalities, one major factor being hair loss. Hypothyroidism has often been se

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

n in women. It is often characterized by problems such as lethargy, menstrual imbalance and deceleration of metabolic rate. A

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ll of these factors contribute to hair loss. On the other hand, highly excessive functional activities of the thyroid gland c

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n also cause hair loss.

Hormonal dysfunction within the body has a massive effect on hair loss. Hair loss occurs when dihydr

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

otestosterone (DHT) shrinks the hair follicles and eventually causes them to disappear completely. The problem of hypothyroid

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ism and hyperthyroidism both encourage the conversion process of testosterone into DHT which accelerates hair loss in both me

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

and women of all ages.

Hair loss induced by hormonal abnormalities is serious. This requires immediate action. We suggest t

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

hat if you are in any doubt then simply feel free to call one of our trichologists for advice.

www.thewestminsterpractice.co

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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