E-Articles - Health and Fitness

Hair loss or baldness is a condition in which hair does not grow on the scalp after hair fal

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

l. The most common form of baldness is the development of a hair thinning condition called a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ndrogenic alopecia or male baldness which occurs in adult males.

The nature of hair loss or

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

baldness can vary greatly. These are the types of hair loss

1. Androgenic alopecia: Loss of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hair in men is called as androgenic alopecia.

2. Alopecia areata: Here hair loss occurs in

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

some portions of the head.

3. Alopecia totalis: In this the hair loss occurs over the enti

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e scalp to an extreme limit.

4. Alopecia universalis: This involves the loss of all hair fr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

om the entire body.

The other less common kinds of baldness are:

1) Traction alopecia: Thi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s type of hair loss is mostly observed in people with ponytails who pull their hair with exc

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ssive force while combing. Wearing a hat for more than 8 hours also causes hair loss. The sc

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

alp should breathe at least 7 hours in a day.

2) Telogen effluvioum: Hair loss some times o

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ccurs due to causes like major surgery, poisoning, child birth, chemotherapy severe stress e

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

c and such condition is known as telogen effluvium.

3) Mycotic Infections: Mycotic infectio

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ns can cause massive hair loss.

4) Alopecia areata: This type hair loss is known as spot ba

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ldness and is caused due to autoimmune disorder.

Prevention Methods

A variety of treatment

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

is available for hair loss. However, even today the treatment for alopecia has a limited suc

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

cess rate. Prevention is better than cure is very much applicable to hair loss. It is much e

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

asier to prevent the falling out of healthy hair than re-growing new ones. Regular exercise

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

an help keep androgen levels low naturally and reduce falling of hair. Stress reduction can

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

stop hair loss. A balanced and nutritious diet reduces the falling of hair to a great extent

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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