E-Articles - Health and Fitness

It is well known that men can start losing their hair from their early twenties onwards yet it is still thought of as uncommon for women to loose their hair. However women can experience sudden hair loss when a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

pproaching the menopause with as many as forty percent of women being affected by the condition. There are many different causes for female hair loss including pregnancy, genetics and illness but the menopause

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is the time most women experience the condition.

The Reasons

Increased hair loss and thinning hair as women approach the menopause is due to changes in hormonal levels in the body. In fact noticing hair loss

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

can be one of the first signs of approaching the menopause. It is caused in part by a drop in estrogen (female hormones) levels produced by the ovaries, creating an imbalance between androgen (male hormones) an

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d estrogen hormones. Testosterone is one of the hormones from the androgen group and increases as the estrogen levels fall. For men, testosterone is the hormone commonly associated with causing male pattern hai

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

loss and although produced in much lower quantities in women, it creates a similar hair loss condition. This process is started by testosterone combining with an enzyme called Alpha5 reductase to create a subs

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tance called dihyrotestosterone (DHT). It is the DHT which is responsible for the hair loss. After the menopause the ovaries may continue to produce even more androgens than estrogen and this can result in furt

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

her hair loss. It also doesn’t just affect hair on the scalp but body hair can also become thinner, just the opposite of men who tend to get more body hair as scalp hair thins. Some women however experience no

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

menopausal hair loss or excessive thinning at all, the reasons for this are not yet fully understood.

Treatments and Advice

Many women are prescribed hormone therapy treatment (HRT) to counter some of the mor

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e severe symptoms of the menopause such as hot flashes, night sweats, lack of sleep, mood swings, and sensitive skin. But HRT works by increasing the levels of estrogen to pre-menopausal levels. HRT is therefor

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

also an effective hair loss treatment which reduces testosterone and DHT allowing hair to grow back.

There is also a prescription only drug called spironolactone that instead of raising estrogen levels, works

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

in the opposite way by slowing down the production of androgens (testosterone) in the adrenal glands and ovaries. With less testosterone produced there is less damaging DHT produced and therefore less hair los

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s.

There are also a number of non drug based measures that can be used to slow down menopausal hair loss. For example gently massage the scalp when shampooing to increase blood flow to the hair roots. Also usi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ng good quality conditioners containing natural products like henna, helps to prevent breakage and reduce further hair loss. It is also important to eat a well balanced diet as healthy hair requires the minimum

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

daily intake of the right minerals and vitamins. Try to eat plenty of fish, liver, dairy products, eggs, poultry, meat, etc, for vitamin A, Vitamin B6, folic acid, vitamin B12, also leafy vegetables, orange ju

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ce, avocado, beets and broccoli are a good source of folic acid.

Keep the hair short to help prevent mechanical breakage and have it layered to give the appearance of more volume. Try to avoid damaging the hai

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

r with hot hair dryers and heated hair straighteners and avoid chemically treating the hair with dyes, tints and bleaches.

Conclusions

Hair loss caused by the menopause is a natural process but can be managed

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

through special care and prescribed treatments. If you have any special concerns about this condition it is always advisable to consult your local GP as stress and worrying can make matters worse. Remember tha

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t you are not alone, many women experience the menopause and hair loss but there are now many effective treatments

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

available.

Please visit our web site for more information and advice about the cause of hair loss in a woman

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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