E-Articles - Health and Fitness

Before considering the question of whether smoking and hair loss are connected, it is important to get a little understanding of what goes on in the hair follicles, the tiny little factories responsib

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

le for hair growth.

What's Happening In The Hair Follicle

The bulb shaped dermal papilla located at the bottom of the hair follicle creates new cells which push upwards forcing older cells ev

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

en higher. When these cells get to the middle of the hair follicle they die and harden and begin to form a central core which eventually becomes a new hair shaft.

On what is the dermal papilla depend

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ent in order to keep up the production of new cells? A healthy blood supply. The hair follicle is fed by a network of tiny blood vessels which provide the needed oxygen and nutrients necessary for hai

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

growth.

Smoking And Blood Circulation

Now back to the question of smoking and hair loss. What effect does smoking have on the blood supply and the circulatory system?

Here is a short list:

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

Nicotine causes an increase in adrenaline which in turn increases blood pressure and suddenly makes the heart beat faster.

Nicotine causes blood vessels to constrict which in turn

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

makes it harder for the heart to pump blood through the arteries which in turn impacts the blood circulatory system.

Smoking produces carbon monoxide which inhibits the blood's capacity to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

carry oxygen.

Seeing a healthy scalp and healthy hair follicles are so dependent on a rich supply of oxygenated blood which can deliver all the proteins and nutrients needed for new hair

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rowth, it is only reasonable to conclude smoking and hair loss can be connected.

Of course, every individual is different and will respond in a different way to foods, substances, drugs and medicatio

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ns. However, as a general rule, smoking can be seen to have a negative effect on hair growth.

Learning From Mice

Interestingly, a report published in the National Library of Medicine from the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genoa, Italy, indicated a connection between smoking and hair loss with tests carried out on mice.

After 3 mo

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

nths of exposure to cigarette smoke, most of the mice developed areas of alopecia and grey hair. The report stated: "Smoke-exposed mice had extensive atrophy of the epidermis, reduced thickness of the

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

subcutaneous tissue, and scarcity of hair follicles."

So if hair loss is causing you anxiety and you are a smoker, you owe it to yourself to take definite steps to stop smoking as soon as possible. (

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

See resource box below for free online guide)

The Whole Body Approach

Of course, smoking and hair loss is just one part of the story. Combating hair loss involves a number of other factors to

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

o such as diet, nutrition, exercise and proper breathing.

In his ebook "Hair Loss No More" leading hair loss analyst Jonathon E. Phillips sets out a plan which includes all the factors mentioned abov

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

e in order to stop hair loss and promote new hair growth.

He strongly discourages smoking in view of the impact it has on the body's circulatory system and gives detailed instructions on how to train

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the body to breathe properly while doing rudimentary exercises that can make a huge difference, not only to one's general sense of well-being, but especially to the health and condition of the scalp a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nd hair follicles. (See resource box below for more information on this 168 page guide on hair loss)

While there will always be those who contest whether smoking is really damaging to the health, des

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

pite the weight of evidence to now support that conclusion, anyone concerned about hair loss surely needs to consider this matter seriously.

From the evidence available it appears there is definitely

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a connection between smoking and hair loss. In your strategy to cope with hair loss and improve the condition of your head hair, be sure to include a 'Quite Smoking' program if you are a tobacco user

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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